Serum antibody response to Chlamydia trachomatis TroA and HtrA in women with tubal factor infertility

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
Tiina RantsiM Puolakkainen

Abstract

Persistent genital chlamydial infection may lead to tubal factor infertility (TFI). Chlamydia trachomatis TroA and HtrA are proteins expressed during persistent chlamydial infection in vitro. We studied serum IgG antibody response against these proteins by EIA in women with TFI and in subfertile women without tubal pathology. Altogether, 22 of 258 subfertile women (8.5%) had TFI which was unilateral in 17 cases and bilateral in 5 cases. Overall, 55 (21.3%) of the 258 women had TroA and 39 (15.1%) had HtrA antibodies. Seropositivity to TroA and HtrA was more common among women with TFI than women with other causes for subfertility (45.5 vs. 19.1%, p = 0.004 for TroA; 36.4 vs. 13.1%, p = 0.004 for HtrA). Mean absorbance values and the prevalence of TroA and HtrA antibodies increased with increasing severity of TFI. On the basis of our results, TroA and HtrA serology has the potential to be further developed to a specific biomarker for C. trachomatis-related TFI.

References

Jun 10, 1998·Human Reproduction·J A LandV J Goossens
Dec 8, 2000·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·M GencayM Puolakkainen
May 28, 2010·The Journal of Infectious Diseases·Priscilla B Wyrick
Sep 18, 2016·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K HokynarM Puolakkainen
Jun 9, 2017·Future Microbiology·James W MarshWilhelmina M Huston
Jul 14, 2017·The Lancet Infectious Diseases·Magnus UnemoChristopher K Fairley

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Citations

Aug 17, 2021·The Journal of Infectious Diseases·Patrick J HornerWilliam M Geisler

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Methods Mentioned

BETA
nucleic acid amplification

Software Mentioned

SPSS
STATA

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