Serum anticholinergic activity and behavior following atropine sulfate administration in the rat

Pharmacology, Biochemistry, and Behavior
E O'HareJ R Mach

Abstract

Anticholinergic agents such as atropine and scopolamine have long been suggested to produce delirium-like states in humans and experimental animals. Evidence for an anticholinergic mechanism in the pathogenesis of human delirium has accumulated, leading to studies of the behavioral effects of the anticholinergic drug atropine in animals. The current study addresses the adequacy of animal models of delirium in terms of sensitivity, specificity and pharmacological relevance. A multiple fixed-ratio fixed-interval reinforcement schedule was used to test the effects of relatively low doses of atropine on behavior in rats. Additionally, total serum anticholinergic activity (SAA) was measured under dose and time course conditions identical to those used in the behavioral study. Atropine reduced high and low rates of responding in a dose-dependent manner, and SAA increased in a dose dependent manner. SAA at atropine doses of 0.1 mg/kg to 1.0 mg/kg was similar to that found in delirious humans. These behavioral and serum level data suggest that relatively low doses of atropine, substantially below those used in previous attempts to model delirium using rats, may be more pharmacologically relevant to delirium and may minimize non-specifi...Continue Reading

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Citations

Apr 12, 2002·Behavioural Processes·Amy L. Odum
Dec 25, 2004·Medical Hypotheses·Jean-David Gaudreau, Pierre Gagnon
Dec 18, 2013·European Journal of Internal Medicine·Vaishnav KrishnanLouis R Caplan
Aug 25, 2007·Anesthesia and Analgesia·Alex BekkerThomas Blanck
Jul 3, 2008·Journal of the American Veterinary Medical Association·Andrea L LooneyUNKNOWN Association of Shelter Veterinarians' Spay and Neuter Task Force

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