Serum apelin is associated with left ventricular hypertrophy in untreated hypertension patients

Journal of Translational Medicine
Lijun YeYuanlin Ding

Abstract

Apelin is an endogenous ligand for the G protein-coupled receptor APJ. The association between apelin and cardiac modeling has been reported. However, if serum apelin affect the left ventricular hypertrophy (LVH) prevalence in hypertensive patients remains unknown. We enrolled 344 untreated hypertensive patients. The presence of LVH was determined by echocardiography. The blood was drawn from these patients and serum apelin level was detected. To study the direct effect of apelin on cardiac hypertrophy, cardiomyocytes were cultured and were transfected with apelin gene. Morphometric analysis and measurement of protein contain per cell were then performed. We observed a significantly lower serum apelin level in hypertensive patients with LVH compared with those without LVH. Receiver operating characteristic analyses shows that serum apelin level is robust in discriminating patients with LVH from those without. Our in vitro study showed that cellular protein content and cellular size was increased by Ang II treatment, which can be markedly inhibited by the apelin over-expression in cultured cardiomyocytes. Our clinical date established a link between apelin and LVH, suggesting serum apelin may be used as a predicator for LVH prev...Continue Reading

References

Mar 28, 2008·Current Hypertension Reports·Cesare CuspidiAlberto Zanchetti
Jul 9, 2009·JAMA : the Journal of the American Medical Association·Ramachandran S VasanStefan Blankenberg
Apr 20, 2010·FEBS Letters·Camille FoussalOksana Kunduzova
May 28, 2010·Clinical and Experimental Hypertension : CHE·Alper SonmezMustafa Kutlu
Jun 30, 2010·Heart·Gareth BarnesDavid E Newby
Dec 15, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Hidemichi KouzuKazuaki Shimamoto
Jan 26, 2011·Circulation·Mark H Drazner
Feb 25, 2011·Journal of Hypertension·Monika Przewlocka-KosmalaWojciech Kosmala
Nov 16, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Wataru KoguchiToshihiko Ishimitsu
Aug 24, 2013·Medical Hypotheses·Soroush Seifirad, Farzad Masoudkabir
Dec 24, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Heng ZengJian-Xiong Chen
Oct 15, 2014·Journal of Cellular and Molecular Medicine·Xuwei HouJian-Xiong Chen

❮ Previous
Next ❯

Citations

Dec 27, 2018·Journal of Cellular Physiology·Jun ChengLinxi Chen
Jul 28, 2019·Current Opinion in Lipidology·Umar RekhiMaria Febbraio
Dec 6, 2017·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Ibrahim DoganYusuf Karavelioglu
Jun 8, 2018·Frontiers in Physiology·Marta B WysockaDorota Nowak
May 19, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Victoria N ParikhEuan A Ashley
Dec 20, 2019·Hormones : International Journal of Endocrinology and Metabolism·Jun Hyun BaeWook Song
Feb 27, 2021·American Journal of Physiology. Heart and Circulatory Physiology·David CoquerelOlivier Lesur
Apr 11, 2021·Molecular and Cellular Endocrinology·I Castan-LaurellP Valet
May 25, 2021·Frontiers in Cardiovascular Medicine·Shaying YangTingting Zhou

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA
protein assay
transfection
pharmacotherapy

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.