Serum asymmetric dimethylarginine and nitric oxide levels in Turkish patients with acute ischemic stroke

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Mujgan ErcanFatma Meric Yilmaz

Abstract

Nitric oxide synthase (NOS) is present in the brain and cerebral arteries and it enables the synthesis of nitric oxide (NO), which plays a critical role in brain perfusion. Asymmetrical dimethylarginine (ADMA) is an endogenous NOS inhibitor. The aim of this study was to evaluate serum ADMA levels, which are an indicator of endothelial dysfunction of the renal functions in patients with acute ischemic stroke, and to determine whether there is a possible correlation between ADMA and NO levels and the l-arginine-to-ADMA ratio. Fifty-two patients (22 male and 30 female; mean age: 75.2 ±10.1 years) with a diagnosis of acute ischemic stroke in the first 24 h post-stroke and 48 healthy individuals (controls; 13 male and 35 female; mean age: 60.1 ±7.92 years) were included in this study. The risk factors recorded and evaluated were age and gender of the patients, serum lipid levels, serum ADMA levels, nitrate-to-nitrite ratios, l-arginine, l-arginine-to-ADMA ratios, sedimentation rate, C-reactive protein (CRP), urea and creatinine levels, and glomerular filtration ratio (eGFR). The mean serum ADMA level was 0.48 ±0.23 μM for the patients and 0.36 ±0.18 μM for the controls. The mean NO level was 2.78 ±0.59 μM for the patient group and 4...Continue Reading

Citations

Sep 11, 2020·Oxidative Medicine and Cellular Longevity·Maciej BladowskiAdrian Doroszko
Mar 11, 2020·International Journal of Molecular Sciences·Gerrit M GrosseChi-Un Choe
Jan 30, 2021·Neural Regeneration Research·Mushfiquddin KhanJeseong Won
Mar 31, 2021·Neurochemistry International·Satoshi HosokiMasafumi Ihara
Aug 28, 2021·International Journal of Molecular Sciences·Sebastian AndoneRodica Balasa

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