Serum autotaxin levels are associated with Graves' disease

Endocrine Journal
Takahiro NojiriYutaka Yatomi

Abstract

Graves' Disease is a representative autoimmune thyroid disease that presents with hyperthyroidism. Emerging evidence has shown the involvement of lysophosphatidic acid (LPA) and its producing enzyme, autotaxin (ATX), in the pathogenesis of various diseases; among them, the involvement of the ATX/LPA axis in some immunological disturbances has been proposed. In this study, we investigated the association between serum ATX levels and Graves' disease. We measured the levels of serum total ATX and ATX isoforms (classical ATX and novel ATX) in patients with untreated Graves' disease, Graves' disease treated with anti-thyroid drugs, patients with subacute thyroiditis, silent thyroiditis, Plummer's disease, or Hashimoto's thyroiditis, and patients who had undergone a total thyroidectomy, as well as normal subjects. The serum total ATX and ATX isoform levels were higher in the patients with Graves' disease, compared with the levels in the healthy subjects and the patients with subacute thyroiditis. Treatment with anti-thyroid drugs significantly decreased the serum ATX levels. The serum ATX levels and the changes in serum ATX levels during treatment were moderately or strongly correlated with the serum concentrations or the changes in ...Continue Reading

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Citations

Dec 15, 2020·International Journal of Rheumatic Diseases·Yasunori IwataTakashi Wada
Jun 17, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yoshifumi MoritaYutaka Yatomi
Jan 25, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kazuki NakawatariYutaka Yatomi
Nov 28, 2021·Pharmaceuticals·Yi JiaHai Shang

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