Serum bactericidal activity against Enterobacteriaceae producing broad-spectrum beta-lactamases in volunteers administered ofloxacin and cefotaxime, alone or combined

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
P WeberC Carbon

Abstract

The activity of ofloxacin and cefotaxime, alone or combined, against four strains of Enterobacteriaceae was evaluated both in vitro and in sera from volunteers given a single infusion over 30 min of 200 mg ofloxacin or 1 g cefotaxime. The strains showed resistance or decreased susceptibility to third-generation cephalosporins. The combination was not found to be synergistic in vitro. Analysis of the bactericidal titres and killing kinetics of sera taken at the time of the peak concentration and 6 h after the infusion, respectively, confirmed the absence of synergy between the drugs against these strains.

References

Feb 1, 1977·Antimicrobial Agents and Chemotherapy·P F DoughertyT R Matthews
Mar 1, 1985·The Journal of Infectious Diseases·C C Sanders, W E Sanders
May 1, 1987·Antimicrobial Agents and Chemotherapy·L L BricelandJ M Mylotte
Nov 1, 1983·Antimicrobial Agents and Chemotherapy·T A DrakeM A Sande

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