PMID: 3766522Nov 1, 1986Paper

Serum bactericidal and opsonic activities in chronic lymphocytic leukemia and multiple myeloma

American Journal of Hematology
E KansuD Firat

Abstract

Susceptibility to infection is widely recognized as the major cause of morbidity and mortality in patients with CLL and MM. The present study was designed to investigate the serum bactericidal (SBA) and serum opsonic activities (SOA) in 12 CLL and 12 MM patients, and results were compared to 20 normals. SBA and SOA were measured by a new radiometric assay. SBA was found to be normal in 11 patients with CLL and in all 12 patients with MM. In contrast, SOA was significantly lower in 11 out of 12 patients with CLL. Ten of twelve patients with MM also had significantly lower SOA compared to those of controls. No correlation was detected between the serum immunoglobulin and complement levels of the patients or between the degree of the opsonic defect and the incidence of infection. In mixture experiments, untreated normal serum partially corrected the opsonic activity of CLL and MM serum. The results suggest the presence of a possible inhibitor in the serum of patients with two well-known B-lymphocyte-derived disorders.

References

Feb 1, 1978·Infection and Immunity·R C Skarnes
Nov 1, 1979·Southern Medical Journal·W FulkersonB W Davis
May 1, 1973·The Journal of Pediatrics·J A Winkelstein
Oct 1, 1973·Archives of Internal Medicine·J J Twomey
Jan 1, 1974·Scandinavian Journal of Haematology·A Slungaard, M J Smith
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jun 1, 1983·The Journal of Infectious Diseases·H E AkalinH Telatar
Jan 1, 1982·Annals of Internal Medicine·D G SavageT J Garrett

❮ Previous
Next ❯

Citations

Jun 3, 2009·International Journal of Laboratory Hematology·G N KalambokisE V Tsianos
Jan 1, 1988·Critical Reviews in Oncology/hematology·R A Kyle, P A Greipp
Jul 20, 2005·Best Practice & Research. Clinical Haematology·Joan Bladé, Laura Rosiñol

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.