PMID: 6162193Sep 1, 1980Paper

Serum beta 2-microglobulin in acute and chronic leukaemia

Scandinavian Journal of Haematology
J EllegaardK Kragballe

Abstract

The serum concentration of beta 2-microglobulin (beta 2-m) was measured in 69 patients with acute or chronic lympho- and myeloproliferative disorders. Serum beta 2-m was found significantly increased in 12 out of 14 patients with chronic lymphatic leukaemia. The serum concentration was proportional to the estimated lymphatic infiltration of tissues but inversely related to the number of circulating lymphocytes. Cytostatic treatment was followed by a decrease in serum beta 2-m, but normalization of the serum concentration was not observed. 11 patients with chronic granulocytic leukaemia all had significantly elevated serum concentrations of beta 2-m and increased serum concentrations were also found in patients with acute leukaemias. Thus, 12 out of 25 patients with acute myeloid leukaemia and all of 5 patients with acute myelomonocytic leukaemia as well as 4 out of 5 patients with acute lymphatic leukaemia had increased serum beta 2-m levels. In acute leukaemia no correlation could be demonstrated between the blood lymphocyte concentration and serum beta 2-m. Also no significant changes in serum beta 2-m were found in either remission or relapse of the acute leukaemia. It is concluded that serum beta 2-m in patients with chroni...Continue Reading

References

Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·J ShusterM D Poulik
Jul 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·C TeasdaleL E Hughes
Oct 21, 1978·Lancet·B SpatiJ A Child
Jan 1, 1978·Scandinavian Journal of Immunology·F K StevensonG T Stevenson
May 1, 1979·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P L Amlot, M Adinolfi
Dec 1, 1971·Scandinavian Journal of Clinical and Laboratory Investigation·P E EvrinI Berggård
Dec 1, 1973·The Journal of Experimental Medicine·H M GreyJ L Strominger
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·P CresswellR T Kubo
May 1, 1974·British Journal of Haematology·D A GaltonG J Goldenberg
May 17, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·K KithierM D Poulik
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·P A PetersonG M Edelman
Jan 24, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·P E Evrin, L Wibell
Jan 1, 1974·British Journal of Haematology·D CatovskyC V Harrison
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·P E Evrin, L Wibell
Jul 1, 1969·The American Journal of Medicine·L R Zacharski, J W Linman
Feb 1, 1980·Scandinavian Journal of Haematology·B SimonssonK Nilsson

❮ Previous
Next ❯

Citations

May 15, 1985·Cancer·I P ConstantinidesZ Komninos
Mar 28, 1981·British Medical Journal
Jun 15, 1983·Cancer·H HagbergB Simonsson
Jun 1, 1988·British Journal of Haematology·C S ScottB E Roberts
Dec 1, 1982·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·E B PedersenK D Christensen
Apr 1, 1996·Leukemia & Lymphoma·K RemesT T Pelliniemi
Oct 1, 1984·Hematological Oncology·J A Child, M R Kushwaha
Jul 27, 2001·The American Journal of Gastroenterology·M ZissisA Archimandritis
Apr 1, 1982·Scandinavian Journal of Haematology·K SøllingJ Ellegaard

❮ Previous
Next ❯

Related Concepts

Related Feeds

Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a clinically and genetically heterogeneous disease with approximately 20,000 cases per year in the United States. AML also accounts for 15-20% of all childhood acute leukemias, while it is responsible for more than half of the leukemic deaths in these patients. Here is the latest research on this disease.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

AML: Role of LSD1 by CRISPR (Keystone)

Find the latest rersearrch on the ability of CRISPR-Cas9 mutagenesis to profile the interactions between lysine-specific histone demethylase 1 (LSD1) and chemical inhibitors in the context of acute myeloid leukemia (AML) here.