Serum beta2-microglobulin concentration as a novel marker to distinguish levels of risk in acute heart failure patients

Journal of cardiology
Keisuke KawaiMitsuhiro Yokoyama

Abstract

Recently, serum beta2-microglobulin, an endogenous marker for renal function, has been shown to be an independent predictor of mortality in older adults. However, the prognostic role of beta2-microglobulin in heart failure has not been elucidated. We prospectively evaluated serum beta2-microglobulin and creatinine concentrations, creatinine-based renal parameters (estimated glomerular filtration rate and creatinine clearance), and echocardiographic data in 131 patients with acute heart failure and creatinine concentrations < or =3.0mg/dL admitted to our hospitals. During 2.3+/-1.3 years, 42 patients died of cardiovascular causes and 12 died of noncardiac causes. Cardiovascular events were observed in 63 patients: 53 were readmitted due to worsening heart failure, 5 readmitted for cerebral embolism, and 5 died from sudden cardiac death. According to multivariate stepwise Cox proportional hazard analysis, higher baseline serum beta2-microglobulin concentrations (X(2)=16, p<0.0001), previous congestive heart failure (X(2)=11, p<0.001), presence of chronic obstructive pulmonary disease (X(2)=8, p<0.01), and lower diastolic blood pressure (X(2)=6, p<0.05) were independent predictors of increased cardiovascular events. Also, higher b...Continue Reading

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Citations

Feb 11, 2014·Clinics in Laboratory Medicine·Petr Jarolim
Sep 11, 2013·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Nathalie NeirynckRaymond Vanholder
May 28, 2016·International Journal of Cardiology·Vasiliki V GeorgiopoulouAndreas P Kalogeropoulos
Feb 9, 2018·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Martin SiebeckDetlef Kindgen-Milles
Jun 18, 2019·European Heart Journal·Ferran RuedaAntoni Bayés-Genís
Nov 27, 2019·Current Heart Failure Reports·Alexander S MangubaAnuradha Lala
Apr 21, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Wenping MaoKewu Huang
Jun 29, 2021·International Journal of Cardiology·Sayaki IshiwataTohru Minamino

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