Serum betatrophin concentrations are significantly increased in overweight but not in obese or type 2 diabetic individuals

Obesity
Kaifeng GuoWeiping Jia

Abstract

In this study, circulating serum betatrophin levels were quantitated and their relationships with insulin resistance (IR) and other metabolic parameters in Chinese subjects with varying degrees of obesity and glucose tolerance were examined. Serum betatrophin levels were determined using ELISA in 60 subjects with normal glucose tolerance (NGT: 17 lean, 23 overweight, and 20 obese subjects) and 56 subjects with type 2 diabetes mellitus (T2DM: 14 lean, 23 overweight, and 19 obese subjects). The associations of serum betatrophin levels with adiposity, glucose, lipid profile, and hepatic enzyme parameters were studied. Serum betatrophin concentrations were significantly higher in overweight subjects in both the NGT and T2DM groups; however, no significant difference between lean and obese participants was observed. No significant difference was found between males and females or between NGT and T2DM subjects. Serum betatrophin concentrations correlated positively with fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR), γ-glutamyl transpeptidase (γ-GT), and alanine aminotransferase (ALT) in all subjects. Serum betatrophin concentrations showed an independent association with γ-GT and HOMA-IR. Serum ...Continue Reading

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Citations

Mar 5, 2016·European Journal of Gastroenterology & Hepatology·Hasan Gurel, Teoman Dogru
Dec 24, 2015·Journal of Diabetes Research·Sheyu LiHaoming Tian
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Dec 7, 2018·Journal of Atherosclerosis and Thrombosis·Hanako NikiYukihiko Momiyama
Feb 20, 2020·Journal of Clinical Medicine·Leonardo Catalano-IniestaMaría José García-Barrado
Mar 11, 2020·American Journal of Physiology. Endocrinology and Metabolism·Lu ZhangLuke Norton
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Sep 29, 2021·Open Biology·Chang GuoGuoyue Yuan

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