Serum Bile Acid Levels in Children With Nonalcoholic Fatty Liver Disease

Journal of Pediatric Gastroenterology and Nutrition
Jörg JahnelValerio Nobili

Abstract

Because the prevalence of obesity in children is increasing, the frequency of pediatric nonalcoholic fatty liver disease (NAFLD) is growing. A reliable noninvasive biomarker for monitoring progression of liver fibrosis would be useful. In cirrhotic persons serum bile acid (BA) levels are significantly elevated. We hypothesized that BA levels and composition in pediatric NAFLD vary depending on the stage of fibrosis. Children with NAFLD were compared with controls and classified by stages of fibrosis (NAFLD-F0, n = 27; NAFLD-F≥1, n = 65) based on liver-biopsy findings. Fasted metabolic and cholestasis status was assessed by several blood tests. BA profiles were measured by tandem mass spectrometry and compared with healthy controls (n = 105). Compared with controls, all of the NAFLD patients were overweight and showed significantly elevated glucose, insulin, aspartate transaminase, and alanine transaminase levels. Total serum BAs were lower in nonfibrotic NAFLD children than in a control cohort (1.73 vs 3.6 μmol/L) because low glycine-conjugated BA levels were incompletely compensated by increases in taurine-conjugated or unconjugated BA. In patients with fibrotic NAFLD, BA levels were lower than in controls (2.45 vs 3.6 μmol/L)...Continue Reading

References

May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C BabbsT W Warnes
Apr 1, 1988·European Journal of Clinical Investigation·E AndersénJ Sjövall
Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E WisseR S McCuskey
Jan 1, 1982·Digestion·G A MannesG Paumgartner
Sep 24, 1999·Biochemical and Biophysical Research Communications·H MitsuyoshiK Kashima
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Jun 9, 2005·Gastroenterology·Vlad RatziuUNKNOWN LIDO Study Group
Sep 8, 2006·Journal of Endocrinological Investigation·E CacciariA Cicognani
Oct 4, 2006·Pediatrics·Jeffrey B SchwimmerCynthia Behling
Jun 26, 2007·Trends in Molecular Medicine·Stefano FiorucciLuca Santucci
Apr 11, 2009·World Journal of Gastroenterology : WJG·Maria-J Perez, Oscar Briz
Sep 3, 2009·Cell Metabolism·Charles ThomasKristina Schoonjans
Nov 17, 2009·QJM : Monthly Journal of the Association of Physicians·J K DowmanP N Newsome
May 4, 2010·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Lucas Maillette de Buy Wenniger, Ulrich Beuers
May 13, 2010·Digestive Diseases·Michael TraunerMartin Wagner
Sep 30, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Valerio NobiliMassimo Pinzani
Apr 14, 2011·Journal of Clinical Pathology·Mayumi ChibaYasuni Nakanuma
Jul 13, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Peizhen SongCurtis D Klaassen
Aug 5, 2011·Cold Spring Harbor Symposia on Quantitative Biology·S KirD J Mangelsdorf
Dec 15, 2012·Journal of Hepatology·Valerio NobiliPietro Vajro
Jan 30, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Richard SkoienAndrew D Clouston
Nov 14, 2013·Seminars in Liver Disease·Claudia FuchsMichael Trauner
Nov 21, 2013·Biomarker Research·Steven G PearceJen-Jung Pan
Mar 15, 2014·Current Opinion in Gastroenterology·Jason M RidlonJasmohan S Bajaj
Apr 16, 2014·Trends in Endocrinology and Metabolism : TEM·Janne PrawittBart Staels
Jun 27, 2014·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jörg JahnelMichael Trauner

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Citations

May 17, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Evelyn ZöhrerValerio Nobili
Oct 1, 2016·World Journal of Gastroenterology : WJG·Maria Grazia ClementePietro Vajro
Jan 21, 2021·International Journal of Molecular Sciences·Kaja Blagotinšek CokanTadeja Režen
Apr 7, 2015·Journal of Pediatric Gastroenterology and Nutrition·Emer Fitzpatrick
Jul 20, 2021·The Journal of Clinical Endocrinology and Metabolism·Li QiYongsheng Chen
Aug 7, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Youngae JungUNKNOWN Innovative Target Exploration of NAFLD (ITEN) consortium

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Methods Mentioned

BETA
biopsy
biopsies
enzyme-linked immunosorbent assay

Software Mentioned

SPSS Statistics package

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