Serum Bile Acids in Patients With Primary Open-angle Glaucoma

Journal of Glaucoma
Mridula M JacobShobha Kamath

Abstract

To measure the serum bile acids (SBA) in patients with primary open-angle glaucoma (POAG) and to compare with nonglaucomatous controls. A hospital-based case control study of 90 patients above the age of 40 years was conducted. Patients with POAG formed the study group and individuals without glaucoma in the same age group formed the control group. SBA estimation was done using ELISA kit enzymatic assay technique and the median value was compared between the 2 groups. The median of SBA level was found to be more in POAG patients when compared with the control group. The difference was statistically significant (P<0.001). Median SBA level was not affected by the age or sex of the participants in the study. "Bile acids" may have a role in the oxidative stress and apoptosis involved in the pathophysiology of POAG.

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Citations

Mar 1, 2019·Journal of Glaucoma·Fazil KhurrumMayuri Borgohain

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Methods Mentioned

BETA
ELISA
metabolomics profiling
enzymatic assay

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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