Serum bioactive follicle-stimulating hormone concentrations from prepuberty to adulthood: a cross-sectional study

The Journal of Clinical Endocrinology and Metabolism
I Z BeitinsP C Sizonenko

Abstract

Serum bioactive (B) LH concentrations increase with each pubertal stage and exceed immunoreactive (I) measurements in boys and girls throughout puberty. These results have been attributed to increased GnRH secretion and/or sex steroid modulation. FSH secretion is likewise affected by these factors. We, therefore, tested the hypothesis that serum B-FSH concentrations would increase with each stage of puberty in boys and girls. In this study we compared the serum concentrations of B-FSH, I-FSH, and sex steroids and stages of puberty (determined according to Tanner) in 111 sera obtained from boys and girls from 6-18 yr of age with the results obtained from 6 young men under the age of 35 yr and 13 cycling women (studied during the follicular, periovulatory, and luteal phases of their menstrual cycles). The serum I-FSH, testosterone (T), and estradiol (E2) concentrations were determined by RIAs, and B-FSH was determined by the rat Sertoli cell aromatase induction assay. The results were analyzed by one-way analysis of variance followed by Scheffe's test for each gender and two-way analysis of variance followed by Student-Newman-Keuls test for comparison of the results between sexes. In boys the mean serum T concentrations increased...Continue Reading

Citations

Jul 1, 1996·Journal of Assisted Reproduction and Genetics·C K SitesJ R Brumsted
Sep 1, 1991·Clinical Endocrinology·A TsatsoulisW R Robertson
Dec 1, 1991·Journal of Endocrinological Investigation·M Simoni, E Nieschlag
Nov 7, 2006·Molecular and Cellular Endocrinology·S CampoC Bergadá

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