PMID: 25735368Mar 5, 2015Paper

Serum biomarkers for early detection of hepatocellular carcinoma associated with HCV infection in egyptian patients

Asian Pacific Journal of Cancer Prevention : APJCP
Abdel-Rahman N ZekriGamal Esmat

Abstract

Early detection of hepatocellular carcinoma using serological markers with better sensitivity and specificity than alpha fetoprotein (AFP) is needed. The aim of this study was to evaluate the diagnostic value of serum sICAM-1, β-catenin, IL-8, proteasome and sTNFR-II in early detection of HCC. Serum levels of IL-8, sICAM-1, sTNFR-II, proteasome and β-catenin were measured by ELISA assay in 479 serum samples from 192 patients with HCC, 96 patients with liver cirrhosis (LC), 96 patients with chronic hepatitis C (CHC) and 95 healthy controls. Serum levels of proteasome, sICAM-1, β-catenin and αFP were significantly elevated in HCC group compared to other groups (P-value<0.001), where serum level of IL-8 was significantly elevated in the LC and HCC groups compared to CHC and control groups (P-value <0.001), while no significant difference was noticed in patients with HCC and LC (P-value=0.09). Serum level of sTNFR- II was significantly elevated in patients with LC compared to HCC, CHC and control groups (P-value <0.001); also it was significantly higher in HCC compared to CHC and control groups (P-value <0.001). ROC curve analysis of the studied markers between HCC and other groups revealed that the serum level of proteasome had se...Continue Reading

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Citations

Jul 15, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Hanaa H AhmedNadia S Mahmoud
Nov 3, 2017·Molecular Diagnosis & Therapy·Doaa Ali AbdelmonsifDina Mohamed Abdallah
Apr 4, 2019·Interdisciplinary Perspectives on Infectious Diseases·Hanan M FayedMona M AbdelMeguid
Apr 29, 2016·World Journal of Gastroenterology : WJG·Abdel-Rahman Nabawy ZekriAbeer A Bahnassy
Dec 11, 2020·Carcinogenesis·Xiongfeng PanAizhong Liu

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