Serum Biomarkers Indicate Long-term Reduction in Liver Fibrosis in Patients With Sustained Virological Response to Treatment for HCV Infection

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Mei LuChronic Hepatitis Cohort Study Investigators

Abstract

Sustained virological response (SVR) to antiviral therapy for hepatitis C virus (HCV) correlates with changes in biochemical measures of liver function. However, little is known about the long-term effects of SVR on liver fibrosis. We investigated the effects of HCV therapy on fibrosis, based on the Fibrosis-4 (FIB4) score, over a 10-year period. We collected data from participants in the Chronic Hepatitis Cohort Study-a large observational multicenter study of patients with hepatitis at 4 US health systems-from January 1, 2006, through December 31, 2013. We calculated patients' FIB4 score and the aminotransferase-to-platelet ratio index (APRI) score over a 10-year period. Of 4731 patients with HCV infection, 1657 (35%) were treated and 755 (46%) of these patients achieved SVR. In propensity score-adjusted analyses, we observed significant longitudinal changes in FIB4 score that varied with treatment and response to treatment. In patients achieving SVR, FIB4 scores decreased sharply, remaining significantly lower over the 10-year period than in untreated patients or patients with treatment failure (P < .001). In independent analyses, men and patients with HCV genotype 1 or 3 infections had higher FIB4 scores than women or patie...Continue Reading

References

Jun 1, 1992·Journal of Clinical Epidemiology·R A DeyoM A Ciol
Sep 17, 2008·Annals of Internal Medicine·Vincent MalletStanislas Pol
Dec 17, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sarah L GeorgeAdrian M Di Bisceglie
Jul 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul J PockrosAnna S Lok
Jan 25, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roberta D'AmbrosioPierre Bedossa
Sep 20, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne C MoormanUNKNOWN Chronic Hepatitis Cohort Study Investigators
Dec 12, 2012·General Hospital Psychiatry·Carol S NorthMauricio Lisker-Melman
Apr 18, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott D HolmbergUNKNOWN Chronic Hepatitis Cohort Study (CHeCS) Investigators
Jan 30, 2014·Journal of Viral Hepatitis·J LiUNKNOWN Chronic Hepatitis Cohort Study (CHeCS) Investigators
Nov 12, 2014·AIDS·Amrita DaftaryNesri Padayatchi
Dec 9, 2014·JAMA Internal Medicine·Adeel A ButtUNKNOWN ERCHIVES (Electronically Retrieved Cohort of HCV Infected Veterans) Study Team
Sep 19, 2015·Health Services & Outcomes Research Methodology·Adam SteventonJasjeet S Sekhon

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Citations

Sep 20, 2016·Journal of Hepatology·Norah A Terrault, Tarek I Hassanein
Dec 8, 2016·Nature Reviews. Gastroenterology & Hepatology·Aaron P ThriftFasiha Kanwal
Jun 22, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Mei LuStuart C Gordon
Jul 25, 2017·Journal of Clinical Gastroenterology·Stuart C GordonUNKNOWN CHeCS investigators
Mar 14, 2019·Current Opinion in Gastroenterology·Don C Rockey
Mar 12, 2019·Expert Review of Anti-infective Therapy·Lai Wei, Yi-Hsiang Huang
Jun 22, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fasiha KanwalHashem B El-Serag
Aug 3, 2017·World Journal of Gastroenterology : WJG·Diogo Libânio, Rui Tato Marinho
Aug 1, 2019·Liver International : Official Journal of the International Association for the Study of the Liver·Mubarak SayyarGuadalupe Garcia-Tsao
Apr 3, 2018·PloS One·Makan GolizehUNKNOWN Canadian Co-Infection Cohort (CTN222)
Mar 30, 2019·Current Hepatology Reports·Feng Su, George N Ioannou
Jul 28, 2020·International Journal of Clinical Pharmacy·Abdel-Hameed Ibrahim Mohamed EbidRadwa Samir Hagag
Aug 2, 2017·Liver International : Official Journal of the International Association for the Study of the Liver·Tarik AsselahAlessandra Mangia
Oct 9, 2020·Journal of Clinical Gastroenterology·Robert J WongUNKNOWN Hepatocellular Carcinoma Research Committee of the Chronic Liver Disease Foundation
Nov 1, 2020·Nature Reviews. Gastroenterology & Hepatology·Tatiana Kisseleva, David Brenner
Dec 15, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jerry R MendellJacques P Tremblay
Feb 3, 2021·Gastroenterology·Don C Rockey, Scott L Friedman
Jun 20, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Lindsey A GeorgeKatherine A High
Jun 24, 2017·Gastroenterology·Fasiha KanwalHashem B El-Serag

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