Serum Biomarkers of Allergic Contact Dermatitis: A Pilot Study

International Archives of Allergy and Immunology
Auksė ZinkevičienėIrutė Girkontaitė

Abstract

Allergic contact dermatitis (ACD) is an inflammatory skin disease caused by repeated skin exposure to contact allergens. The goal of this pilot study was to identify inflammatory proteins which can serve as biomarkers for ACD. We measured levels of 102 cytokines, chemokines, and growth factors in the sera of 16 ACD patients during acute and remission phases, and 16 healthy volunteers. Serum levels of adiponectin, chemokine (C-C motif) ligand 5 (CCL5), C-reactive protein (CRP), chitinase 3-like 1 (CHI3L1), complement factor D (CFD), endoglin, lipocalin-2, osteopontin, retinol-binding protein 4 (RBP4), and platelet factor 4 (PF4) were significantly higher, whereas levels of trefoil factor 3 (TFF3) were significantly lower, in ACD patients than in healthy controls. In ACD patients, serum levels of CCL5 were elevated, whereas levels of TFF3, soluble intercellular adhesion molecule-1 (sICAM-1), and platelet-derived growth factor (PDGF)-AB/BB were found to be lower during the remission phase of the disease. Serum levels of adiponectin, CCL5, CRP, CHI3L1, CFD, endoglin, lipocalin-2, osteopontin, RBP4, PF4, and TFF3 might be exploited as biomarkers for ACD, whereas levels of CCL5, TFF3, sICAM-1, and PDGF-AB/BB might be exploited for ev...Continue Reading

Citations

Jul 10, 2018·F1000Research·Stefan F MartinJacob P Thyssen
Oct 13, 2020·The Korean Journal of Internal Medicine·Byung-Keun KimYoon-Seok Chang
Jun 10, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Alexandra M RascuCarmen C Diaconu
Apr 30, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·Zhijia FanZhicheng Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
Sahar E El-DeekNahed A Mohamed
Acta Obstetricia Et Gynecologica Scandinavica
Y OkamotoM Ueki
Arteriosclerosis, Thrombosis, and Vascular Biology
Moniek P M de MaatKaare Christensen
© 2022 Meta ULC. All rights reserved