Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer

The American Journal of Clinical Nutrition
Kristin A GuertinRashmi Sinha

Abstract

Coffee intake may be inversely associated with colorectal cancer; however, previous studies have been inconsistent. Serum coffee metabolites are integrated exposure measures that may clarify associations with cancer and elucidate underlying mechanisms. Our aims were 2-fold as follows: 1) to identify serum metabolites associated with coffee intake and 2) to examine these metabolites in relation to colorectal cancer. In a nested case-control study of 251 colorectal cancer cases and 247 matched control subjects from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we conducted untargeted metabolomics analyses of baseline serum by using ultrahigh-performance liquid-phase chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry. Usual coffee intake was self-reported in a food-frequency questionnaire. We used partial Pearson correlations and linear regression to identify serum metabolites associated with coffee intake and conditional logistic regression to evaluate associations between coffee metabolites and colorectal cancer. After Bonferroni correction for multiple comparisons (P = 0.05 ÷ 657 metabolites), 29 serum metabolites were positively correlated with coffee intake (partial correlat...Continue Reading

Citations

Oct 2, 2015·Current Opinion in Biotechnology·Sooah KimKyoung Heon Kim
Jan 2, 2016·International Journal of Epidemiology·Fangyi GuNeil E Caporaso
Mar 10, 2016·Nature Reviews. Clinical Oncology·Susan T MayneCheryl L Rock
Nov 17, 2015·Trends in Cancer·Ryan M Thomas, Christian Jobin
Nov 9, 2015·American Journal of Clinical Dermatology·Yik Weng YewRobert A Schwartz
Sep 12, 2015·Journal of Agricultural and Food Chemistry·Silke S HeinzmannPhilippe Schmitt-Kopplin
May 31, 2016·Journal of Cancer Epidemiology·Erik J GroesslMarcia L Stefanick
May 14, 2016·Japanese Journal of Clinical Oncology·Shamima AkterUNKNOWN ; for the Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
Sep 22, 2016·Journal of Gastroenterology·Kazuhiko UchiyamaYuji Naito
Feb 2, 2017·Journal of Proteome Research·Aoife O'GormanLorraine Brennan
Jan 25, 2018·International Journal of Epidemiology·Lucie LécuyerMathilde Touvier
Apr 25, 2018·Molecular Nutrition & Food Research·Lorraine Brennan, Frank B Hu
Feb 16, 2018·International Journal of Cancer. Journal International Du Cancer·Ikuko KashinoUNKNOWN Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan
Oct 20, 2018·The American Journal of Clinical Nutrition·Ling-Wei ChenUNKNOWN Lifeways Cross Generation Cohort Study
Mar 30, 2019·The American Journal of Psychiatry·Antonio F PardiñasJames T R Walters
May 26, 2016·The Proceedings of the Nutrition Society·Helena Gibbons, Lorraine Brennan
Aug 24, 2017·European Journal of Clinical Nutrition·A L RoncoG Sanchez
Sep 5, 2019·Molecular Nutrition & Food Research·Joseph A RothwellAugustin Scalbert
Jan 11, 2020·The American Journal of Clinical Nutrition·Marilyn C Cornelis
Oct 21, 2017·Oncotarget·Jiaqi HuangDemetrius Albanes
Jul 13, 2018·Genes & Nutrition·Joseph A RothwellAugustin Scalbert
Mar 11, 2020·British Journal of Cancer·Erikka Loftfield, Neal D Freedman
Aug 12, 2016·The American Journal of Clinical Nutrition·Mary C PlaydonSteven C Moore
Apr 17, 2018·Metabolomics : Official Journal of the Metabolomic Society·Qian XiaoCharles E Matthews
Oct 19, 2017·Journal of Internal Medicine·M C CornelisE Ingelsson
May 28, 2019·Current Nutrition Reports·Emma E McGeeA Heather Eliassen
Jul 11, 2019·Molecular and Clinical Oncology·Nurul Azmir Amir HashimMusalmah Mazlan
May 18, 2018·The American Journal of Clinical Nutrition·Øivind MidttunPer M Ueland
Jan 13, 2018·Journal of the National Cancer Institute·Steven C MooreRegina G Ziegler
Mar 5, 2019·Metabolomics : Official Journal of the Metabolomic Society·Eline H van RoekelKrista A Zanetti
Sep 15, 2018·Genes & Nutrition·Pedapati S C Sri HarshaLorraine Brennan
Nov 17, 2016·Nature Reviews. Gastroenterology & Hepatology·Stephen J D O'Keefe
Jun 21, 2019·Molecular Nutrition & Food Research·Dorrain Yanwen LowClaudine Manach
Oct 20, 2020·Expert Opinion on Drug Metabolism & Toxicology·Tariq IsmailCarmela Fimognari
Nov 27, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lucie LécuyerMathilde Touvier
Sep 23, 2020·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Mehmet KanbayBaris Afsar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Jeannette M SchenkUlrike Peters
© 2021 Meta ULC. All rights reserved