Serum biomarkers of inflammation and adiposity in the LABS cohort: associations with metabolic disease and surgical outcomes

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Robert W O'RourkeBruce M Wolfe

Abstract

The utility of serum biomarkers related to inflammation and adiposity as predictors of metabolic disease prevalence and outcomes after bariatric surgery are not well-defined. Associations between pre- and post-operative serum levels of four biomarkers (C-reactive protein (CRP), cystatin C (CC), leptin, and ghrelin) with baseline measures of adiposity and metabolic disease prevalence (asthma, diabetes, sleep apnea), and weight loss and metabolic disease remission after bariatric surgery were studied in the Longitudinal Assessment of Bariatric Surgery (LABS) cohort. Baseline CRP levels were positively associated with the odds of asthma but not diabetes or sleep apnea; baseline CC levels were positively associated with asthma, diabetes, and sleep apnea; baseline leptin levels were positively associated with asthma and negatively associated with diabetes and sleep apnea; baseline ghrelin levels were negatively associated with diabetes and sleep apnea. Increased weight loss was associated with increased baseline levels of leptin and CRP and decreased baseline levels of CC. Remission of diabetes and asthma was not associated with baseline levels of any biomarker. A higher likelihood of asthma remission was associated with a greater d...Continue Reading

Associated Clinical Trials

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Citations

Jun 9, 2018·Diabetes/metabolism Research and Reviews·Sharon Li Ting PekSubramaniam Tavintharan
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Jul 21, 2020·Current Opinion in Pharmacology·Justine FaramiaAndré Tchernof

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Methods Mentioned

BETA
gastric bypass

Clinical Trials Mentioned

NCT00433810

Software Mentioned

SAS

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