Serum biomolecules unable to compete with drug refilling into cyclodextrin polymers regardless of the form

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Nathan A RohnerHorst A von Recum

Abstract

Polymers that are refillable and sustain local release will have a great impact in both preventing and treating local cancer recurrence as well as addressing non-resectable diseases. Polymerized cyclodextrin (pCD) disks, which reload drugs into molecular "pockets" in vivo through affinity interactions, have been previously shown to localize doxorubicin (Dox) to treat glioblastoma multiforme. However, one concern is whether drug refilling is influenced by competition from local biomolecules. In addition the impact of the polymer form on drug refilling is unknown. Herein, different pCD formulations were synthesized from γ-cyclodextrin (γ-CD) and were compared in vitro using competitive drug filling/refilling assays. Data reveal that affinity-based drug refilling occurs as a function of both the polymer form and the sustained release polymeric liquid (SRPL) dilution factor, pointing to the surface/volume ratio, as well as the CD pocket density, and the effects of the distance between pocket. In vitro refilling experiments with cholesterol demonstrated no interference with Dox filling of the CD polymer, while the presence of albumin only slightly reduced Dox filling of pCD-γ-MP (microparticle) and pCD-γ-SRPL forms, but not pCD-γ-di...Continue Reading

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Citations

May 23, 2020·International Journal of Molecular Sciences·Rebecca M HaleyEvon S Ereifej
Mar 21, 2020·Pharmaceutics·Nathan A RohnerHorst A von Recum
Aug 28, 2020·Acta Biomaterialia·Alan Dogan, Horst von Recum
Jan 19, 2021·ACS Biomaterials Science & Engineering·Stephanie L McNamaraDavid J Mooney

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Methods Mentioned

BETA
surface plasmon resonance
biopsy
chip
xenograft

Software Mentioned

Autodock
Biacore
Autodock Vina

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