Serum-borne factors alter cerebrovascular endothelial microRNA expression following particulate matter exposure near an abandoned uranium mine on the Navajo Nation.

Particle and Fibre Toxicology
Bethany SanchezKatherine E Zychowski


Commercial uranium mining on the Navajo Nation has subjected communities on tribal lands in the Southwestern United States to exposures from residual environmental contamination. Vascular health effects from these ongoing exposures are an active area of study. There is an association between residential mine-site proximity and circulating biomarkers in residents, however, the contribution of mine-site derived wind-blown dusts on vascular and other health outcomes is unknown. To assess neurovascular effects of mine-site derived dusts, we exposed mice using a novel exposure paradigm, the AirCARE1 mobile inhalation laboratory, located 2 km from an abandoned uranium mine, Claim 28 in Blue Gap Tachee, AZ. Mice were exposed to filtered air (FA) (n = 6) or concentrated ambient particulate matter (CAPs) (n = 5) for 2 wks for 4 h per day. To assess miRNA differential expression in cultured mouse cerebrovascular cells following particulate matter (PM) exposure (average: 96.6 ± 60.4 μg/m3 for all 4 h exposures), the serum cumulative inflammatory potential (SCIP) assay was employed. MiRNA sequencing was then performed in cultured mouse cerebrovascular endothelial cells (mCECs) to evaluate transcriptional changes. Results indicated 27 highl...Continue Reading


Jan 1, 1987·Journal of Cell Science. Supplement·P J DonovanC C Wylie
Oct 25, 2002·Journal of Toxicology and Environmental Health. Part a·Matthew J CampenWilliam P Watkinson
Jan 8, 2004·Genome Biology·Anton J EnrightDebora S Marks
Oct 29, 2005·Stroke; a Journal of Cerebral Circulation·Gregory A WelleniusMurray A Mittleman
Feb 7, 2006·Current Biology : CB·Sabbi LallNikolaus Rajewsky
Sep 9, 2008·Trends in Cell Biology·Sarah Roush, Frank J Slack
Oct 29, 2008·Genome Research·Robin C FriedmanDavid P Bartel
Jan 15, 2013·Molecular Neurobiology·Menaka C ThounaojamAnirban Basu
May 8, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sarah RobertsonMatthew J Campen
May 9, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Timothy E O'TooleAruni Bhatnagar
Aug 13, 2014·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·David L PennE Sander Connolly
Oct 18, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alicia M BoltKoren K Mann
Nov 8, 2014·Nucleic Acids Research·Nathan Wong, Xiaowei Wang
May 13, 2015·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael L PaffettMatthew J Campen
Dec 15, 2015·Molecular BioSystems·Guangchuang Yu, Qing-Yu He
Jan 24, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mario AragonMatthew J Campen
Feb 13, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christen L MumawMichelle L Block
Mar 10, 2016·Particle and Fibre Toxicology·Rodosthenis S RodosthenousAndrea A Baccarelli
Nov 20, 2016·Environmental Monitoring and Assessment·Aminur RahmanShahruk Nur-A-Tomal
Dec 3, 2016·Particle and Fibre Toxicology·Christina R TylerMatthew J Campen
Jan 26, 2017·Journal of Exposure Science & Environmental Epidemiology·Molly E HarmonMatthew J Campen
Feb 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Mario J AragonMatthew J Campen
Apr 28, 2017·Current Environmental Health Reports·Johnnye LewisDebra MacKenzie
Jun 18, 2017·Environmental Science & Technology·Cong LiuHaidong Kan
Feb 1, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Christina R TylerMatthew J Campen
Apr 17, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katherine E ZychowskiMatthew J Campen
Apr 21, 2018·Annals of the American Thoracic Society·Martha PowersAna Navas-Acien
Oct 10, 2018·Current Environmental Health Reports·Nour AssadKatherine E Zychowski
Nov 24, 2018·Journal of Cellular and Molecular Medicine·Shao WangXi Li

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Mar 9, 2021·Journal of Toxicology and Environmental Health. Part a·Alexis WilsonKatherine E Zychowski

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