Serum brain-derived neurotrophic factor and cortical thickness are differently related in patients with schizophrenia and controls

Psychiatry Research
Andre ZugmanElisa Brietzke

Abstract

Brain-derived neurotrophic factor (BDNF) has been implicated in neuronal plasticity, a key process related to the pathophysiology of schizophrenia. However, the relationship of peripheral levels of BDNF to cortical thickness and subcortical structures has not been extensively investigated. This study aims to investigate the relationship of peripheral serum BDNF levels to cortical thickness and volumes of the hippocampus and amygdala. Twenty-nine patients with schizophrenia and 32 healthy controls were included in this study. Structural magnetic resonance imaging (MRI) scans obtained in a 1.5 T scanner were performed in all subjects. Images were processed using Freesurfer software. Blood samples were collected on the same day of the MRI scan for BDNF peripheral levels. Vertex-wise analysis revealed significantly thinner cortex in patients compared with controls. BDNF levels and cortical thickness showed different patterns of correlation for patients and healthy controls in one cluster in the right hemisphere distributed across the supramarginal, postcentral, and inferior frontal cortices.

References

Jan 1, 1987·Schizophrenia Bulletin·S R KayL A Opler
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Oct 19, 1999·Human Brain Mapping·K J WorsleyA C Evans
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Mar 20, 2001·Nature Reviews. Neuroscience·M M Poo
Oct 12, 2001·Schizophrenia Research·N DuranyJ Thome
Dec 4, 2002·Nature Reviews. Neuroscience·Carlos Vicario-AbejónMenahem Segal
Mar 1, 2003·Molecular Psychiatry·P MugliaJ L Kennedy
May 21, 2003·Acta Psychiatrica Scandinavica. Supplementum·J M HaroUNKNOWN SOHO Study Group
Jun 26, 2003·The Journal of Clinical Psychiatry·Scott W Woods
Sep 10, 2003·Archives of General Psychiatry·Gina R KuperbergBruce Fischl
Jun 29, 2004·NeuroImage·F SégonneB Fischl
Oct 27, 2004·NeuroImage·Bruce FischlAnders M Dale
Jan 5, 2005·Molecular Psychiatry·M Neves-PereiraD M St Clair
Apr 13, 2007·IEEE Transactions on Medical Imaging·Florent SégonneBruce Fischl
Apr 20, 2007·Neuroscience Letters·Clarissa Severino GamaFlavio Kapczinski
Sep 25, 2007·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Maurício Silva de LimaFernando Madalena Volpe
Jul 2, 2008·Expert Review of Neurotherapeutics·Flavio KapczinskiRodrigo Grassi-Oliveira
Feb 9, 2011·Archives of General Psychiatry·Aristotle N VoineskosJames L Kennedy
Oct 28, 2011·Journal of Psychiatric Research·Gabriela FavalliZafiris Jeffrey Daskalakis
Nov 3, 2011·Neuroscience Letters·Cristiano Souza NotoElisa Brietzke
May 23, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Elisa BrietzkeRoger S McIntyre
May 31, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gwyneth C M ZaiJames L Kennedy
Oct 9, 2012·Schizophrenia Bulletin·Sander V HaijmaRené S Kahn
Jun 1, 2013·Schizophrenia Research·André ZugmanAndrea P Jackowski
Feb 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chao WangTianzi Jiang

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Citations

May 12, 2016·Expert Opinion on Therapeutic Targets·Francesca CalabreseRaffaella Molteni
Jun 11, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Geraldo Busatto FilhoFabio L Duran
Dec 24, 2018·American Journal of Physical Anthropology·Tyler Hill, John D Polk
Jul 22, 2017·Journal of Alzheimer's Disease : JAD·Anandhi IyappanUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 12, 2021·Journal of Psychiatric Research·Mariane Nunes NotoRodrigo Affonseca Bressan

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