Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Breno S DinizOrestes Vicente Forlenza

Abstract

The aim of the present study is to investigate serum BDNF levels in older depressed patients as compared to healthy elderly controls. Twenty-nine elderly subjects with major depression and 42 healthy older adults were enrolled to this study. All depressed patients were antidepressant-free for at least 1 month prior clinical and laboratorial assessments. Serum BDNF levels were determined by sandwich ELISA. BDNF levels were lower in elderly depressed patients as compared to controls (P=0.034). Patients with late-onset depression had the lowest BDNF level (median 478.5, interquartile range 373.5-740.9 pg/l) when compared to early-onset depression (median 620.7, interquartile range 366.1-971.9 pg/l) and healthy controls (median 711.3, interquartile range 534.7-1181.0 pg/l) (P<0.03). Reduced serum BDNF level may be a state marker of late-life depression in non-medicated elderly patients. Our findings provide further evidences that reduced neurotrophic support may have an important role in the physiopathology of late-life depression.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Oct 24, 1997·Archives of General Psychiatry·G S AlexopoulosM Charlson
Oct 14, 2000·Experimental Neurology·C R AlmliD M Holtzman
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jun 7, 2005·Lancet·George S Alexopoulos
Dec 20, 2005·Journal of Neural Transmission·C LaskeK Schott
Mar 24, 2006·Journal of Psychiatric Research·Christoph LaskeKlaus Schott
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Aug 2, 2006·Neurobiology of Aging·Andreas A ZiegenhornRainer Hellweg
Jan 11, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Joost JanssenThea J Heeren
Aug 25, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·L L HerrmannK P Ebmeier
Oct 4, 2007·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Warren D TaylorK Ranga R Krishnan
Nov 9, 2007·European Archives of Psychiatry and Clinical Neuroscience·T LeyheC Laske
Feb 8, 2008·Genes, Brain, and Behavior·K SchindowskiL Buée
Feb 12, 2008·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Warren D TaylorK Ranga R Krishnan
Apr 3, 2008·Current Opinion in Psychiatry·Perminder SachdevWei Wen
May 21, 2008·Biological Psychiatry·Joel R SneedSteven P Roose
Aug 30, 2008·The International Journal of Neuropsychopharmacology·André Russowsky BrunoniFelipe Fregni
Dec 10, 2008·Archives of Neurology·Markus Britschgi, Tony Wyss-Coray
Jan 15, 2009·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Breno Satler DinizOrestes Vicente Forlenza

❮ Previous
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Citations

Jul 27, 2012·Translational Psychiatry·S E ArnoldL M Shaw
Oct 23, 2013·PloS One·Maria GieseAnne Eckert
Apr 17, 2012·Drugs & Aging·Orestes V ForlenzaWagner F Gattaz
Dec 8, 2010·Biomarkers in Medicine·Antonio Lucio TeixeiraArthur Kummer
Aug 26, 2014·The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences·Breno S DinizOrestes V Forlenza
Sep 3, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Masahiro HashizumeKazushige Ihara
Sep 8, 2011·Neuromolecular Medicine·Breno Satler Diniz, Antonio Lucio Teixeira
Jan 14, 2016·Annals of Medicine·Karen SchmittAnne Eckert
May 25, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Orestes Vicente ForlenzaWagner Farid Gattaz
Feb 15, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Breno Satler DinizOrestes Vicente Forlenza
Mar 3, 2011·Neuroscience Letters·Rafael T de SousaRodrigo Machado-Vieira
May 23, 2012·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Yu PeiXin Ma
Nov 4, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Antonio TerraccianoDavid Schlessinger
Apr 8, 2014·Psychoneuroendocrinology·Annemarie van der MeijRichard C Oude Voshaar
Oct 4, 2011·Journal of Psychiatric Research·Breno S DinizOrestes V Forlenza
Apr 23, 2013·Archives of Physical Medicine and Rehabilitation·Daniele S PereiraLeani S Máximo Pereira
May 21, 2016·Frontiers in Psychiatry·Juan Joseph YoungCharles Raymond Marmar
Jan 1, 2011·International Journal of Psychiatry in Medicine·Sheng-Chiang SuYi-Jen Hung
Nov 4, 2016·BMC Medicine·Howard J AizensteinOren Tene
Oct 22, 2013·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Orestes V ForlenzaWagner Gattaz
Mar 13, 2014·Current Opinion in Psychiatry·Florindo StellaOrestes V Forlenza
Feb 1, 2018·Praxis·Martin HatzingerEgemen Savaskan
Jan 22, 2019·Expert Opinion on Therapeutic Targets·Nina K Popova, Vladimir S Naumenko
Dec 22, 2019·European Archives of Psychiatry and Clinical Neuroscience·Giuseppe FanelliChiara Fabbri
Jun 11, 2020·Life·Federico MucciLiliana Dell'Osso
Mar 2, 2021·Frontiers in Behavioral Neuroscience·Beatrice ArosioIvan Aprahamian
Sep 9, 2018·Journal of Psychiatric Research·Apoorva BhandariDaniel M Blumberger
Jun 23, 2021·Journal of the International Neuropsychological Society : JINS·Vonetta M DotsonZachary N Salling
Jul 25, 2021·International Journal of Environmental Research and Public Health·Eugenia Murawska-CiałowiczAdilson Marques
Sep 11, 2018·Dementia and Geriatric Cognitive Disorders·Michele LauriolaAntonio Greco

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