Serum C-reactive protein as an important prognostic variable in patients with diffuse large B cell lymphoma.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Ye CaoWen-qi Jiang

Abstract

C-reactive protein (CRP) is an acute-phase reactant that is a promising biomarker in patients with cancer of many kinds. The aim of this retrospective study was to evaluate significant changes in CRP levels as a parameter for the response effect and long-term survival of patients with diffuse large B cell lymphoma (DLBCL). Serum CRP data were collected in 94 patients with DLBCL from October 2006 to August 2009 in Cancer Center, Sun Yat-Sen University. Results were correlated with clinical data. The median CRP serum level in patients with DLBCL was 30.91 ± 53.35 in male and 22.39 ± 29.89 mg/L in female. Base line CRP levels were correlated with International Prognostic Index (IPI) scores (p = 0.03). Among the patients with an IPI score of 1-2, base line CRP levels were correlated with long-term survival (p = 0.001). Base line CRP levels were also correlated with OS (p = 0.001) and varied with different clinical stages (p = 0.03). The corresponding CRP levels in the patients with 2 cycles of chemotherapy were correlated with short-term treatment response (p = 0.003) and OS (p = 0.04) or TTP (p = 0.03). CRP serum levels can be used as additional prognostic parameter in patients with diffuse large B cell type lymphoma.

References

Mar 1, 1989·Cleveland Clinic Journal of Medicine·S D Deodhar
Apr 7, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J KodamaT Kudo
May 21, 1999·Science·J A HoffmannR A Ezekowitz
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Hirofumi NakanishiHideki Yoshikawa
Feb 6, 2004·JAMA : the Journal of the American Medical Association·Thomas P ErlingerKathy J Helzlsouer
Nov 9, 2004·Biochemical and Biophysical Research Communications·Alexander SchmeisserChristoph D Garlichs
Jun 22, 2005·Current Treatment Options in Oncology·Daniel Morgensztern, Izidore S Lossos
Oct 11, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Lorraine MarnellTerry W Du Clos
Apr 21, 2006·Cardiovascular Research·Elaine Paffen, Moniek P M DeMaat
Jul 10, 2007·Gynecologic Oncology·Stephan PolterauerLukas A Hefler
Jul 20, 2007·European Journal of Haematology·Yair HerishanuElizabeth Naparstek
Aug 19, 2007·Journal of Epidemiology and Community Health·Katriina HeikkiläDebbie A Lawlor
Sep 26, 2007·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Justine Schuller Gortney, Rhonda Martin Sanders
Feb 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lukas A HeflerAlexander Reinthaller
Jun 9, 2009·Oral Oncology·Sunil D KhandavilliRhiannon Whitaker
Mar 23, 2010·Cell·Sergei I GrivennikovMichael Karin

❮ Previous
Next ❯

Citations

May 7, 2013·BMC Cancer·Sandra SteffensAndres J Schrader
Sep 10, 2015·Leukemia Research·Kazuho MiyashitaYoshiaki Ishigatsubo
Jun 6, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jing WangJian Ouyang
Nov 11, 2018·Annals of Hematology·Se-Il GoGyeong-Won Lee
Oct 30, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Mark JaradehJawed Fareed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.