Serum C-reactive protein concentration as an indicator of remission status in dogs with multicentric lymphoma

Journal of Veterinary Internal Medicine
Lise NielsenJoanna S Morris

Abstract

The acute-phase protein C-reactive protein (CRP) is used as a diagnostic and prognostic marker in humans with various neoplasias, including non-Hodgkin's lymphoma. To evaluate if CRP could be used to detect different remission states in dogs with lymphoma. Twenty-two dogs with untreated multicentric lymphoma. Prospective observational study. Blood samples were collected at the time of diagnosis, before each chemotherapy session, and at follow-up visits, resulting in 287 serum samples. Before therapy, a statistically significant majority of the dogs (P = .0019) had CRP concentrations above the reference range (68%, 15/22). After achieving complete remission 90% (18/20) of the dogs had CRP concentrations within the reference range, and the difference in values before and after treatment was statistically significant (P < .001). CRP concentrations of dogs in complete remission (median, 1.91; range, 0.2-103) were significantly different (P = .031) from those of dogs with partial remission (median, 2.48; range, 0-89), stable disease (median, 1.77; range, 1.03-42.65), or progressive disease (median, 8.7; range, 0-82.5). There was profound variation of CRP measurements within each dog. CRP is useful in determining complete remission s...Continue Reading

Citations

May 28, 2011·Journal of Veterinary Internal Medicine·V MukoreraA Goddard
Sep 2, 2014·The Veterinary Clinics of North America. Small Animal Practice·Stephanie E Schleis
Jul 14, 2010·The Veterinary Journal·P D Eckersall, R Bell
Dec 20, 2013·Journal of Veterinary Internal Medicine·S J ViitanenM M Rajamäki
May 13, 2015·Veterinary Clinical Pathology·Anne-Katherine JasenskyBarbara Kohn
May 24, 2016·Journal of Veterinary Internal Medicine·K A SeltingP O Pithua
Jun 9, 2016·The Journal of Small Animal Practice·S M CraigJ A Lidbury
Dec 30, 2016·Journal of Veterinary Internal Medicine·S J ViitanenM M Rajamäki
Feb 15, 2017·Veterinary and Comparative Oncology·M Milovancev, D S Russell

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