Serum C-reactive protein is an independent risk factor predicting cardiometabolic risk

Metabolism: Clinical and Experimental
A OnatG Hergenç

Abstract

The aim of the study was to investigate the role of serum C-reactive protein (CRP) level as a risk factor in predicting metabolic syndrome (MS), hypertension, atherogenic dyslipidemia, type 2 diabetes mellitus, and coronary heart disease. We prospectively evaluated 1270 men and 1320 women, aged 30 to 89 years, who had serum CRP determinations and a mean 4.3 years' follow-up. The CRP values were log-transformed for calculations. Metabolic syndrome was defined by the Adult Treatment Panel III criteria modified for male abdominal obesity. Prediction of outcome was performed by excluding from analysis the particular outcome variable existing at baseline examination. Smoking men had higher age-adjusted estimated CRP concentrations (P < .001), whereas smoking women had lower CRP (P = .027) than never smokers. Risk of developing an elevated (> or =2 mg/L) CRP was predicted significantly by baseline CRP in both sexes and by apolipoprotein (apo B), current smoking, and family income in men, when adjusted for 5 further variables. Baseline CRP levels predicted atherogenic dyslipidemia when adjusted for age, baseline dyslipidemia values, and apo B tertiles and predicted incident hypertension independent of age, waist circumference, and smo...Continue Reading

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Citations

Dec 11, 2008·Metabolic Syndrome and Related Disorders·Ike S Okosun
Jul 10, 2010·International Journal of Environmental Research and Public Health·Fatma G HuffmanSubrata Nath
Feb 20, 2014·International Journal of Endocrinology·Assim A Alfadda
May 23, 2014·Archives of Dermatological Research·Tiago TorresManuela Selores
May 6, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Agata CzarnywojtekMarek Ruchała
Feb 9, 2016·Indian Journal of Clinical Biochemistry : IJCB·Suparna RoyAnindya Dasgupta
Feb 6, 2016·Expert Review of Cardiovascular Therapy·Altan OnatAyşem Kaya
Apr 14, 2009·Diabetes Research and Clinical Practice·Abdolali EbrahimiZahra Sanjdideh
Jun 28, 2008·International Journal of Cardiology·Altan OnatGülay Hergenç
Jul 1, 2010·Cell Biochemistry and Function·Vanusa ManfrediniCarmen Regla Vargas
May 15, 2015·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Altan OnatEvin Ademoğlu
Aug 13, 2008·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Altan OnatSerkan Bulur
Jul 16, 2011·Expert Opinion on Pharmacotherapy·Altan Onat
Jul 9, 2009·The Journal of Clinical Endocrinology and Metabolism·Murielle BochudValentin Rousson

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