PMID: 8943750Oct 1, 1996Paper

Serum CagA antibodies in asymptomatic subjects and patients with peptic ulcer: lack of correlation of IgG antibody in patients with peptic ulcer or asymptomatic Helicobacter pylori gastritis

Journal of Clinical Pathology
D Y GrahamJ E Crabtree

Abstract

Several studies have suggested that Helicobacter pylori which express CagA may be more virulent than those that do not, but limited populations have been studied to date. The aim of this study was to confirm and extend the association of CagA positive H pylori strains in a different geographical area and to a large, well defined patient population. A validated ELISA for serum IgG to CagA was used to investigate the prevalence of CagA seropositivity in 100 patients with peptic ulcer compared with 77 with H pylori infection without ulcer disease in a North American population. The extent of antral and corpus inflammation and H pylori density in relation to CagA seropositivity in 40 subjects with H pylori infection were assessed semiquanitatively. All studies were carried out in a coded and blinded manner. The prevalence of serum IgG CagA antibodies was higher in H pylori infected patients with ulcer (59%) compared with healthy H pylori infected volunteers (44%), but the difference was not significant. In contrast, the titre of serum IgG anti-CagA antibodies was higher among the seropositive subjects without ulcer disease, but again the difference was not significant. Comparison of histological features between asymptomatic indivi...Continue Reading

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Citations

Oct 13, 2000·Gastroenterology Clinics of North America·M F Go, S E Crowe
Jun 23, 1999·FEMS Immunology and Medical Microbiology·T AlarcónM López-Brea
Oct 26, 2000·Alimentary Pharmacology & Therapeutics·D VairaM Miglioli
Jan 4, 2001·Clinical and Diagnostic Laboratory Immunology·T IkenoueM Omata
Apr 3, 2001·Journal of Clinical Microbiology·C FigueiredoL J van Doorn
Nov 28, 2002·Journal of Clinical Microbiology·Chang-Young ParkYoshio Yamaoka
Jul 1, 1997·Journal of Clinical Pathology·F FraggettaN Figura
Dec 12, 1997·Gastroenterology·D Y Graham
Jan 29, 2010·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Valeska Portela LimaSílvia Helena Barem Rabenhorst
Dec 9, 2015·The American Journal of Emergency Medicine·Yusuf TanrikuluErcan Bicakci
Mar 28, 1998·Scandinavian Journal of Gastroenterology·M F GoD Y Graham
Aug 1, 1997·Scandinavian Journal of Gastroenterology·H M MalatyD Y Graham
Mar 28, 1998·The American Journal of Gastroenterology·M SozziA Carbone
Jul 1, 1997·Journal of Clinical Pathology·D Slater
Jul 1, 1997·Journal of Clinical Pathology·S J Nayler, K Cooper
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