Serum calcitonin negative medullary thyroid carcinoma: a systematic review of the literature

Clinical Chemistry and Laboratory Medicine : CCLM
Pierpaolo Trimboli, Luca Giovanella

Abstract

Generally, calcitonin (CT) values below the upper reference limit rule-out medullary thyroid carcinoma (MTC) with very high accuracy. However, sparse cases of serum-calcitonin-negative MTC (CT-NEG-MTC) have been reported. Here we reviewed CT-NEG-MTC reported in literature, discussed the potential causes and proposed a practical laboratory and clinical approach. A comprehensive literature search was conducted by using the terms "medullary thyroid carcinoma" AND "non-secreting calcitonin" OR "undetectable calcitonin". The search was updated until December 2014. Original articles that described CT-NEG-MTC were eligible for inclusion. Only MTC cases with preoperative CT below the upper reference limit were included in the present review. Eleven papers with 18 CT-NEG-MTC cases (age 50 years, size 26 mm) were retrieved. Four patients with poorly differentiated MTC died within 3 years. Different CT assays were employed and different reference values were adopted. Preoperative serum CT values were below the institution cut-off levels in all cases, and undetectable in four patients. In some papers negative CT results were confirmed by additional tests. Further laboratory investigations were performed in some of the included studies. In ...Continue Reading

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Citations

Oct 21, 2015·Diagnostic Cytopathology·Pierpaolo TrimboliLuca Giovanella
Apr 30, 2016·Journal of Cancer Research and Clinical Oncology·Maria Teresa SamàEmanuela Arvat
Nov 2, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Pierpaolo TrimboliLuca Giovanella
Dec 20, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Luca GiovanellaPierpaolo Trimboli
Mar 5, 2019·Chinese Medical Journal·Qian-Qian GuoQing Chang
Dec 24, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Claudia CipriFranco Grimaldi
Sep 5, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Luca GiovanellaMarkus Luster
Oct 19, 2016·Clinical Chemistry and Laboratory Medicine : CCLM·Marina Parra-RobertRafael Molina
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May 31, 2019·BMC Endocrine Disorders·Claudio GambardellaGiovanni Docimo
Jun 28, 2018·Endocrinology and Metabolism·Pierpaolo Trimboli, Luca Giovanella
Feb 12, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Xianming LiangGuoyang Wu
Oct 22, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Luca GiovanellaLuca Ceriani
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Mar 3, 2021·International Journal of Surgical Pathology·Jae Yeon SeokXuemo Fan
Apr 17, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Luca GiovanellaGaetano Paone

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