PMID: 6627696Sep 1, 1983

Serum calcium concentration in hyperthyroidism at diagnosis and after treatment

Clinical Endocrinology
J G DalyR L Himsworth

Abstract

In a large, mainly outpatient, series of hyperthyroid patients who attended a district general hospital the serum concentrations of calcium and albumin were measured before and in many cases after treatment. The calcium level (mean +/- SD) before treatment (2.41 +/- 0.21 mmol/l, n = 437) was significantly higher (P less than 0.01) than afterwards (2.36 +/- 0.15 mmol/l, n = 232) and the albumin level rose when the patients became euthyroid (from 40.5 +/- 3.1 g/l to 44.0 +/- 2.4 g/l; P less than 0.01). After treatment neither value differed from those of an unselected group of out-patients. The usual relation between the serum concentrations of calcium and albumin did not hold in the hyperthyroid subjects but reverted to normal on treatment; the variation, probably due to an increase in ionized calcium, leads to an overestimate of the 'corrected calcium' when conventional methods are used to calculate this figure. Thus, using a conventional formula 8.5% of our hyperthyroid patients would appear to have a calcium greater than 2.65 mmol/l (normal mean plus 2 standard deviations) whereas using a correction factor specific for the hyperthyroid situation the figure is reduced to 5.7% which is only twice the expected proportion. The ca...Continue Reading

References

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Citations

May 1, 1997·Biological Trace Element Research·G SimsekG Candan
Nov 1, 1983·Irish Journal of Medical Science·J R Hayes, C M Ritchie
Sep 9, 2015·Environmental Science and Pollution Research International·Nusrat Shahab MemonMuhammad Waris
Nov 26, 2010·Rheumatic Diseases Clinics of North America·Sabeen Anwar, Allan Gibofsky
Feb 13, 2002·Mayo Clinic Proceedings·Grace Kho Dy, Elaine B York
Mar 21, 2007·Clinical Endocrinology·Mathis GrossmannHelena Teede
Sep 30, 2010·European Journal of Clinical Investigation·Luca GiovanellaLuca Ceriani
May 1, 1985·Clinical Endocrinology·R M GreenwoodR L Himsworth
Jul 1, 1992·The American Journal of Medicine·D L Geffner, J M Hershman
Jul 22, 2005·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jonathan R Insel, Nimrita Dhanjal
Jan 1, 1988·Journal of Endocrinological Investigation·G BenkerD Reinwein
Mar 14, 2018·World Journal of Surgery·Jacob EnellJoakim Hennings

Related Concepts

Calcium
Hyperthyroidism
Plasma Albumin
Cytomel

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