Serum Calcium Predicts Cognitive Decline and Clinical Progression of Alzheimer's Disease.

Neurotoxicity Research
Ling-Zhi MaJin-Tai Yu

Abstract

Relationship between serum calcium and Alzheimer's disease (AD) remains unclear. The aim of this study is to test whether serum calcium is associated with other AD-associated biomarkers and could predict clinical progression in nondemented elders. This was a longitudinal population-based study. The sample was derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, which included 1224 nondemented elders: 413 cognitively normal (CN) and 811 mild cognition impairment (MCI). Associations were investigated between serum calcium and longitudinal changes in Aβ/tau pathologic features, brain structure, cognitive function, and disease progression. Serum calcium concentrations increased with disease severity. Serum calcium predicted longitudinal cognitive decline and conversion from nondemented status to AD dementia (adjusted HR = 1.41, 95% CI 1.13-1.76). Furthermore, serum calcium levels were negatively correlated with CSF-Aβ42 (β = - 0.558, P = 0.008), FDG-PET (β = - 0.292, P < 0.001), whole brain volume (β = - 0.148, P = 0.001), and middle temporal volume (β = - 0.216, P = 0.042). Similar results were obtained in CN and MCI groups. Higher serum calcium status (even if not hypercalcemia) may increase the risk of AD ...Continue Reading

References

Jul 1, 1991·Neurobiology of Aging·M N SubhashS K Shankar
Dec 15, 1973·British Medical Journal·R B PayneJ R Milner
Aug 5, 1998·Lancet·D A Bushinsky, R D Monk
Mar 20, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Reijo S TilvisTimo E Strandberg
Sep 18, 2004·Trends in Neurosciences·Emil C ToescuPhilip W Landfield
Nov 6, 2007·Journal of the American Geriatrics Society·Miranda T SchramRudi G J Westendorp
Dec 19, 2008·Journal of Endocrinological Investigation·M D Walker, S J Silverberg
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 14, 2009·Neurology·W J JagustUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 16, 2009·The New England Journal of Medicine·Richard S HotchkissPaul E Swanson
Jun 12, 2010·Neurobiology of Aging·Liana G ApostolovaUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jan 18, 2011·NeuroImage·Daoqiang ZhangUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 31, 2012·Brain Imaging and Behavior·Laura E GibbonsUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 12, 2012·Brain Imaging and Behavior·Paul K CraneUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
May 7, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Frank JessenUNKNOWN Subjective Cognitive Decline Initiative (SCD-I) Working Group
Jun 6, 2014·Journal of Alzheimer's Disease : JAD·Tilly EichlerWolfgang Hoffmann
Jul 22, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·James A HendrixMaria C Carrillo
Mar 31, 2018·EMBO Reports·Cristine BetzerPoul Henning Jensen
Mar 1, 2019·Journal of Alzheimer's Disease : JAD·Kenichiro SatoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative, and Japanese Alzheimer’s Disease Neuroimaging Initiative
Jun 12, 2020·Proceedings of the National Academy of Sciences of the United States of America·Ronald YurkoBernie Devlin

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.