Serum carbohydrate antigen 125 levels in nonischemic dilated cardiomyopathy: a useful biomarker for prognosis and functional mitral regurgitation

Congestive Heart Failure
Oguz KaracaMuhsin Turkmen

Abstract

The authors investigated the prognostic relevance of serum carbohydrate antigen 125 (CA125) levels in nonischemic dilated cardiomyopathy (NICMP) and assessed whether increased levels relate to the degree of functional mitral regurgitation (FMR). Seventy-seven patients with NICMP were enrolled and followed-up for 10 ± 2 months in this prospective study. Receiver-operating characteristic analysis established a cutoff CA125 value of 25 U/mL for predicting mortality. Patients were divided into two groups according to their CA125 levels (CA125 <25 U/mL [n=58] and CA125 ≥ 25 U/mL [n=19]). Patients with high CA125 values had statistically worse functional status, higher B-type natriuretic peptide (BNP) levels, higher left ventricular volumes, lower ejection fraction, higher E/Em ratio, higher pulmonary artery systolic pressure, and more severe FMR. On the multivariate analysis, serum CA125 (P=.002) and severe FMR (P=.04) were identified as the independent predictors of mortality. Serum CA125 levels also correlated with BNP levels and FMR severity (P<.001). Serum CA125 is a powerful prognostic biomarker that is associated with the severity of heart failure, serum BNP levels and several echocardiographic parameters including left ventri...Continue Reading

References

Apr 2, 2002·Gynecologic Oncology·Kerstin SjövallNina Einhorn
May 15, 2002·Progress in Cardiovascular Diseases·Martin R Cowie, Gustavo F Mendez
Jan 12, 2005·European Journal of Heart Failure·Pompilio FaggianoLivio Dei Cas
Apr 9, 2005·European Heart Journal·Patrizio LancellottiLuc A Piérard
Nov 29, 2005·European Journal of Heart Failure·Feridun KosarErcan Varol
Apr 2, 2008·International Journal of Cardiology·Johannes Steiner, Maya Guglin
May 16, 2008·The New England Journal of Medicine·Eugene Braunwald
Mar 17, 2009·International Journal of Cardiology·Sílvia MonteiroLuís A Providência
Sep 9, 2010·Heart, Lung & Circulation·Kenneth A Sikaris
Nov 17, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Simon Ray

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Citations

Aug 9, 2013·Heart Failure Reviews·Julio NúñezJuan Sanchis

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