PMID: 9660027Jul 11, 1998Paper

Serum carcinoembryonic antigen as a prognostic factor in resectable gastric cancer

Journal of the American College of Surgeons
M TachibanaN Nagasue

Abstract

Carcinoembryonic antigen (CEA) has been widely accepted as a tumor marker useful in the diagnosis and management of colorectal cancer. When CEA levels are positive in gastric cancer patients, they could be useful prognostic indicators. However, the value of CEA as a tumor marker for gastric cancer remains a matter of controversy. We measured preoperative serum CEA levels in 196 patients with resectable gastric cancer between May 1986 and April 1996 and then evaluated the correlation between serum CEA levels, clinicopathologic features, and prognostic information. Serum levels of CEA were above the normal range in 29 of 196 (14.8%) surgically resected patients (range, 5.2-570 ng/mL). Among 100 early gastric cancers confined to the submucosal layer, only 7 patients (7.0%) had positive CEA levels, but among 96 advanced cancers, 22 patients (22.9%) had high CEA levels. The CEA positive patients had more macroscopically infiltrative tumors, a more prominent serosal invasion, more frequent lymph nodes involvement, and a more advanced stage than did the CEA negative patients. The 3- and 5-year cumulative disease-specific survival rates of patients positive for serum CEA were 39.6% and 31.7%, respectively; these rates for patients nega...Continue Reading

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Citations

Apr 11, 2013·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Hideaki ShimadaYutaka Takahashi
May 26, 2010·Journal of Gastrointestinal Cancer·Esther Uña Cidón, Rosa Bustamante
May 14, 2005·Critical Reviews in Oncology/hematology·Vincenzo CatalanoEric Van Cutsem
Mar 7, 2003·American Journal of Surgery·Satoshi OhnoNaofumi Nagasue
Mar 1, 2008·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Seong-Hoon ParkWansik Yu
Sep 1, 2009·Expert Opinion on Medical Diagnostics·Jan BornscheinPeter Malfertheiner
Feb 24, 2009·Critical Reviews in Oncology/hematology·Vincenzo CatalanoEric Van Cutsem
Nov 28, 2012·Asia-Pacific Journal of Clinical Oncology·Jae-Cheol JoYoon-Koo Kang
Aug 10, 2004·International Journal of Cancer. Journal International Du Cancer·Johanna LouhimoCaj Haglund
May 16, 2014·World Journal of Clinical Oncology·Ze-Bo HuangPing Liu
Oct 31, 2008·British Journal of Cancer·V CatalanoG Catalano
Sep 20, 2007·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jiehua LinShusheng Zhang
Apr 9, 2009·Biomedit︠s︡inskai︠a︡ khimii︠a︡·E P ElistratovaE Iu Rykova
Oct 7, 2006·Current Opinion in Gastroenterology·R C MoesingerJ W Harmon
May 27, 2020·British Journal of Cancer·Jun-Peng LinChang-Ming Huang
Apr 2, 2020·The Journal of International Medical Research·Xiang XuYugang Wu
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Shu-Bo TianChao Yan
Sep 20, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad AbbasChen Dingding

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