PMID: 6537913Jan 1, 1984Paper

Serum carcinoembryonic antigen in the diagnosis and prognosis of women with breast cancer

European Journal of Cancer & Clinical Oncology
D Y WangJ L Hayward

Abstract

Serum carcinoembryonic antigen (CEA) has been measured in 628 patients before and 577 patients after treatment for breast cancer. These came from an unselected sequence of 730 women, subsequently diagnosed as having stage I or II breast cancer, referred to Guy's Hospital over a period of nearly 5 yr. CEA was also measured in serum from 238 ostensibly healthy volunteers and 65 women with benign breast disease. CEA measurements were of no diagnostic value. There were more patients with breast cancer with values in excess of 10 ng/ml measured preoperatively (7%) or after mastectomy (5%) than in controls (3%), but the difference is of marginal significance. High levels of CEA were not consistently associated with pathological stage or histological grade. Mastectomy was not associated with any significant change in the distribution of CEA levels. Patients with stage II disease and pre-operative CEA levels over 10 ng/ml has a faster recurrence rate than those with levels of less than 2.5 ng/ml. High levels were also associated with reduced survival. However, such patients comprised about 5% of women presenting with early breast cancer, so that the use of CEA measurements for prognosis is of limited value.

References

Sep 1, 1978·Cancer·D C Tormey, T P Waalkes
Sep 1, 1978·Cancer·R E MyersA Malkin
Feb 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N M BorthwickP A Bell
Dec 1, 1981·European Journal of Cancer & Clinical Oncology·M De Jong-BakkerF J Cleton

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Citations

Jan 1, 1991·Cancer Immunology, Immunotherapy : CII·J F RobertsonA Howell
Jan 1, 1985·Breast Cancer Research and Treatment·D Y Wang, I S Fentiman
May 1, 1991·The Japanese Journal of Surgery·S HagaT Kajiwara
Aug 30, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M DnistrianD C Schwartz
Dec 19, 2013·BioMed Research International·Peppino Mirabelli, Mariarosaria Incoronato
Jul 1, 1988·European Journal of Cancer & Clinical Oncology·P GagliaL Caldarola
Dec 15, 1984·International Journal of Cancer. Journal International Du Cancer·J BurchellJ Taylor-Papadimitriou
Jul 1, 1985·Annals of Clinical Biochemistry·J P Persijn

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