Serum carcinoembryonic antigen levels and proliferating cell nuclear antigen labeling index for patients with colorectal carcinoma. Correlation with tumor progression and survival

Cancer
T NakamuraY Saitoh

Abstract

Clinicopathologic variables, carcinoembryonic antigen (CEA), nuclear DNA ploidy, and proliferating cell nuclear antigen labeling index (PCNA LI) have been studied for their effect on patients with various types of cancer. Thirteen clinicopathologic variables, preoperative serum CEA levels, PCNA LI, DNA ploidy patterns, and survival were studied for 57 colorectal carcinoma patients, and the mutual relation between these variables, tumor progression, and survival were analyzed. Seven variable including undifferentiated adenocarcinoma, deep invasion, lymphatic and venous invasion, node metastasis, liver metastasis, and advanced stages were significantly greater for patients with positive CEA ( > 5.0 ng/mL) than for patients with negative CEA ( < 5.0 ng/ML). Three variables including deep invasion, liver metastasis, and advanced stages were significantly greater for patients with high PCNA LI ( > 49.4%) than for patients with low PCNA LI ( < 49.4%). No significant difference was observed in any of the variable for patients with DNA diploid or aneuploid cancer. A close relationship representing a formula, Y (log CEA, ng/mL) = 0.026X (PCNA LI, %) - 0.478, was found between CEA level and PCNA LI: Survival curves for patients with nega...Continue Reading

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Citations

Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·D R SchwartzJ S Lazo
Dec 12, 2012·Journal of Gastroenterology and Hepatology·U Subrahmanyeswara RaoPrema S Rao
Sep 21, 2012·Journal of the Korean Society of Coloproctology·Young Jae RyuHyeong Rok Kim
May 26, 2009·Arquivos De Gastroenterologia·Débora Maria NazatoJaques Waisberg
Mar 29, 2002·The Journal of Pathology·Judith A McKayGraeme I Murray
May 10, 2017·The International Journal of Biological Markers·Changzheng DuJin Gu
Dec 14, 2004·Cancer Immunology, Immunotherapy : CII·Rosalyn D BlumenthalDavid M Goldenberg
Aug 17, 2005·Cancer Investigation·Mitchell J Goldstein, Edith Peterson Mitchell

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