Serum carnitine levels and carnitine esters of patients after kidney transplantation: role of immunosuppression

Metabolism: Clinical and Experimental
Christoph WannerW H Hörl

Abstract

Serum levels of carnitine and carnitine esters were measured in different groups of patients after cadaveric renal transplantation and compared with those of healthy subjects as well as azotemic and uremic patients. In all groups of patients serum levels of total carnitine (TC), free carnitine (FC), short-chain acylcarnitine (SCC), and long-chain acylcarnitine (LCC) increased with reduction of kidney function. However, cyclosporin- and prednisone-treated transplant patients with impaired kidney function displayed significantly higher TC, FC, and SCC compared with transplant patients under immunosuppression with azathioprine and prednisone. This group of cyclosporin-treated patients showed also significantly elevated serum cholesterol suggesting that carnitine deficiency is not responsible for the observed abnormalities in lipid metabolism after renal transplantation. Urinary excretion of TC, FC, SCC, and LCC decreased with reduction of kidney function without differences between cyclosporin- and azathioprine-treated patients. Single dose L-carnitine administration (10 mg/kg body weight IV) resulted in significantly higher TC, FC, SCC, and LCC values of azotemic patients with and without immunosuppression than in healthy subject...Continue Reading

References

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Citations

Sep 1, 1989·Klinische Wochenschrift·W H HörlH Wilms
Jul 1, 1986·Klinische Wochenschrift·C Wanner, W H Hörl
Jan 1, 1990·Journal of Pharmaceutical and Biomedical Analysis·A GlögglerP Fürst
Feb 1, 1997·Transplantation Proceedings·Z ZdrojewskiW Lysiak-Szydłowska
Apr 3, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Oemer-Necmi GoekChrista Meisinger
Jan 5, 2017·PloS One·Roberto BassiPaolo Fiorina
Oct 7, 2005·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Brian Schreiber
Aug 28, 2020·The Kurume Medical Journal·Junko YanoKei Fukami
Jan 21, 2021·Metabolites·Marc R McCannKathleen A Stringer
Mar 4, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shoichiro DaimonMitsuhiro Nishitani

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