Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
László HerszényiFabio Farinati

Abstract

Cathepsin B (CATB) and urokinase-type plasminogen activator (UPA) play an important part in cancer invasion and metastasis. The behavior of CATB and UPA has not been evaluated in the same experimental setting in different gastrointestinal tumors and in precancerous lesions. Serum CATB and plasma UPA levels were determined by enzyme-linked immunoadsorbent assay and their sensitivity, specificity, and diagnostic accuracy have been calculated in patients with colorectal (n=72), gastric (n=30), hepatocellular (n=28), and pancreatic cancer (n=15) as well as in gastric epithelial dysplasia (n=25), colorectal adenomas (n=30), and tumor-free control patients (n=44). Serum CATB and plasma UPA antigen concentrations were significantly higher in patients with cancer than in controls. When all tumors were considered, the sensitivity, specificity, and diagnostic accuracy of CATB (89, 86, and 89%) were higher than that of UPA (76, 70, and 74%). CATB demonstrated in all types of tumors a better diagnostic accuracy than UPA. The positive predictive values of CATB (95%) and UPA (89%) may suggest their use in the evaluation of patients with a suspicion of malignancy. CATB and UPA were significantly higher in patients with gastric epithelial dysp...Continue Reading

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Citations

Aug 13, 2013·Parasitology Research·Vinoth KumarasamySuresh Kumar
Jun 17, 2011·Pathology Oncology Research : POR·Gábor LakatosLászló Herszényi
Sep 14, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrew T ChanShuji Ogino
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Jun 23, 2012·Digestive Diseases·Gábor LakatosLászló Herszényi
Jun 23, 2012·Digestive Diseases·László HerszényiZsolt Tulassay
Jul 10, 2021·Journal of Hepatology·Paloma Ruiz-BlázquezAnna Moles

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