Serum CCL20 combined with IL-17A as early diagnostic and prognostic biomarkers for human colorectal cancer.

Journal of Translational Medicine
Dan WangYi Zhang

Abstract

Noninvasive and effective methods of early diagnosis of colorectal cancer (CRC) are underexplored. Inflammation is known to play an important role in the tumor microenvironment of CRC. Therefore, the aim of this study was to elucidate novel inflammatory biomarkers related to early diagnosis and prognosis of CRC. Based on the results from a multiplex assay and a pan-cancer screening of TCGA data with 18 cancer types, we identified several targeted biomarkers. We further confirmed these results using a trial cohort of 112 CRC patients and 151 controls (59 healthy donors, 52 colitis and 40 colorectal adenoma patients) by Elisa and immunohistochemistry (IHC). The biomarkers expression levels in CRC patients of different clinical stages were compared. The targeted biomarkers panel was developed using logistic regression model and was then validated using an independent cohort including 75 CRC patients and 90 controls (35 healthy donors, 20 colitis and 35 colorectal adenoma patients). Diagnostic accuracy was evaluated using area under the receiver-operating characteristic (ROC) curve and overall survival analysis was used for prognosis. Gene ontology (GO) analyses and Gene set enrichment analyses (GSEA) were performed to predict the ...Continue Reading

References

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·T YoshimuraE J Leonard
May 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gil MorDavid C Ward
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kai-Ping ChangJau-Song Yu
Jan 22, 2013·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Nov 15, 2013·Lancet·Hermann BrennerChristian Peter Pox
Jan 21, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Krasimira AleksandrovaTobias Pischon
Mar 29, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ju-Yu TsengChi-Hung Lin
May 17, 2014·World Journal of Gastroenterology : WJG·Hai-Lin HuangKai-Zhou Jin
Jul 15, 2015·Molecular Carcinogenesis·S MarsiglianteA Muscella
Jul 15, 2015·The International Journal of Biological Markers·Qunying LinXiaobin Gu
Apr 12, 2016·International Journal of Cancer. Journal International Du Cancer·Rushikesh Sudam PatilShubhada Vivek Chiplunkar
Jun 16, 2016·JAMA : the Journal of the American Medical Association·UNKNOWN US Preventive Services Task ForceAlbert L Siu

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Citations

Jul 28, 2020·International Journal of Molecular Sciences·Suguru KadomotoAtsushi Mizokami
Dec 20, 2019·Dose-response : a Publication of International Hormesis Society·Zhi HuangSha-Sha Peng
Dec 17, 2020·The Journal of International Medical Research·Shulong Zhang, Xiaoting Wang
May 11, 2021·Autoimmunity Reviews·Heikrujam Thoihen MeiteiGirdhari Lal

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Methods Mentioned

BETA
flow assay

Software Mentioned

Gene set enrichment analyses ( GSEA )
Elisa
SPSS
GSEA

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