Serum cell adhesion molecules in patients with colorectal cancer

Surgery Today
T KitagawaK Iriyama

Abstract

The serum levels of intercellular adhesion molecule-1 (sICAM-1) and endothelial leukocyte adhesion molecule-1 (sELAM-1) were determined in 40 patients with colorectal cancer. The sICAM-1 and sELAM-1 levels in the drainage venous blood adjacent to a tumor were significantly correlated with those in the peripheral venous blood in patients without evident hematogenous dissemination of tumor cells. The sICAM-1 levels in peripheral venous blood were significantly higher in patients with hepatic metastases, while the sELAM-1 levels were significantly higher in those with pulmonary metastases. An immunohistochemical study of metastatic sites in the liver revealed that ICAM-1 was expressed in cancer stroma, but not in the cancer cells. In conclusion, the sICAM-1 and sELAM-1 levels in the peripheral venous blood in colorectal cancer patients without any distant metastasis are likely to reflect the topical production of these cell adhesion molecules, and appear to be instructive in predicting hematogenous dissemination in patients with colorectal cancer.

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Citations

Jul 10, 2003·The Journal of Surgical Research·Makoto YoshidaKuniyoshi Tanaka
Jun 26, 2010·Japanese Journal of Clinical Oncology·Harunobu SatoKoutarou Maeda
Jan 23, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kayhan ErturkBurak Sakar
Jun 27, 2003·Journal of Surgical Oncology·Mahmut BasogluSabri Selcuk Atamanalp
Sep 20, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tatsuo ShimuraSeiichi Takenoshita
Jan 28, 2006·World Journal of Gastroenterology : WJG·Masanao KurataNobuhiro Ohkohchi
Oct 20, 2018·Oncology Letters·Tatsuo ShimuraShigeru Marubashi

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