Serum Ceramide Reduction by Blueberry Anthocyanin-Rich Extract Alleviates Insulin Resistance in Hyperlipidemia Mice.

Journal of Agricultural and Food Chemistry
Xu SiBin Li

Abstract

Blueberry anthocyanin-rich extract (BAE) was supplemented to high-fat diet (HFD)-fed mice to investigate sphingolipid metabolism modulating factors involved in the attenuated hyperinsulinemia and hyperlipidemia. A BAE-containing diet effectively controlled food intake and liver weight and significantly attenuated insulin resistance triggered by a HFD. Higher BAE (200 mg/kg of body weight) administration performed more efficiently in the improvement of hepatic steatosis and adipocyte hypertrophy, together with distinct suppressions in serum triacylglycerol and cholesterol in total and species. Serum lipid compositions revealed 200 mg/kg of BAE supplementation remarkably suppressed ceramide accumulation. Consistently, genes encoding enzymes associated with sphingomyelin conversion and ceramide de novo synthesis were modulated toward a healthy direction for restrained sphingolipid accumulation. Further, the inhibited mRNA expressions of protein phosphatase 2A and protein kinase Cζ involved in blocking Akt phosphorylation connected the controlled ceramides with the restored insulin sensitivity.

References

Oct 1, 1993·Journal of Internal Medicine·E ShmueliC O Record
Oct 26, 2001·Free Radical Biology & Medicine·C Ramirez-TortosaG G Duthie
Feb 1, 2006·Progress in Lipid Research·Scott A Summers
Jul 21, 2006·Biochimica Et Biophysica Acta·Thomas Kolter, Konrad Sandhoff
Jul 4, 2007·Nutrition Reviews·William L HollandScott A Summers
May 9, 2012·Cell Metabolism·Jose A Chavez, Scott A Summers
Jun 10, 2016·Nature·Rachel J PerryGerald I Shulman
Oct 25, 2016·Advances in Biological Regulation·Nicolas CoantYusuf A Hannun
Nov 23, 2017·Nature Reviews. Molecular Cell Biology·Yusuf A Hannun, Lina M Obeid
Nov 28, 2017·Molecular Nutrition & Food Research·Xu SiChris Blanchard
Mar 9, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chang LiuYun Sun
Nov 28, 2018·Trends in Molecular Medicine·Jennifer KurzSusanne Schiffmann
Oct 12, 2019·Experimental and Therapeutic Medicine·Jing SuiBingyin Shi

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