Serum chitotriosidase activity: is it a new inflammatory marker in obese children?

Journal of Pediatric Endocrinology & Metabolism : JPEM
Ahmet Afsin KundakI Kurt

Abstract

Chitotriosidase (ChT) is an enzyme secreted by activated macrophages and involved in defense against, and in degradation of chitin-containing pathogens, such as fungi, nematodes, and insects. In addition, it plays an important role in the development of atherosclerosis related with systemic low-grade inflammation. To this effect of activity of ChT, we aimed to investigate serum ChT activity in obese subjects and to determine to relation with insulin resistance and high-sensitive C-reactive protein (hsCRP). A total of 73 obese subjects (10.9 +/- 2.6 years of age, 44 male patients) and 41 age and gender-matched healthy lean subjects (11.6 +/- 2.9 years of age, 18 male patients) were included in this study, between 2007 and 2008. The criterion for diagnosing obesity was defined as the body mass index (BMI) being over 97th percentile of the same gender and age. Fasting serum glucose, insulin, hsCRP and ChT levels were measured. We compared the differences in variables between obese and lean subjects with Student's t-test compared after ascertaining that the data were normally distributed. All data were expressed as mean +/- standard deviation. There was statistically significant increase in serum ChT activity of obese subjects, whi...Continue Reading

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Citations

Nov 5, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Sezgin GunesNilgun Kultursay
Dec 19, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Ewa Żurawska-PłaksejAgnieszka Piwowar
Jun 3, 2019·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Elif Ünver Korğalı, Halef Okan Doğan

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