Serum cholesterol and prostate cancer risk in the Finnish randomized study of screening for prostate cancer

Prostate Cancer and Prostatic Diseases
Teemu J MurtolaAnssi Auvinen

Abstract

Hypercholesterolemia has been associated with advanced stage prostate cancer (PCa), but the role of lipid parameters such as HDL and triglycerides is unclear. We examined PCa risk by lipid parameters in a population nested within the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC). Cholesterol measurements were available on 17,696 men. During the 17-year median follow-up, 2404 PCa cases were diagnosed. Cox regression model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI) for overall PCa risk and stratified by Gleason grade and tumor stage. We compared normolipidemic and hyperlipidemic men on four cholesterol parameters total cholesterol (TC), HDL, LDL, and triglycerides (TG), analyzed as time-dependent variables. TC in the highest tertile (above 5.1 mmol/l) and LDL above 3 mmol/l were associated with increased risk of Gleason 8-10 cancer (HR 1.42, 95% CI 1.04-1.95 and HR 1.38, 95% CI 1.02-1.86, respectively). Further, overall PCa risk was elevated in the 3-year lag time analysis by TC in the highest two tertiles (HR 1.27, 95% CI 1.05-1.54 for TC above 4.4 mmol/l, and HR 1.26, 95% CI 1.05-1.51 for TC above 5.1 mmol/l) and HDL in the highest tertile (HR 1.33, 95% CI 1.08-1.64...Continue Reading

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Citations

Sep 25, 2020·Journal of Breath Research·Wiktoria Struck-LewickaMichał Jan Markuszewski
Aug 7, 2020·Journal of Investigative Medicine High Impact Case Reports·Sai Prasad DesikanRaman Desikan
Dec 5, 2020·Medicinal Research Reviews·Henrique J CardosoSílvia Socorro
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Nov 2, 2020·Seminars in Cancer Biology·Shiva GanjaliAmirhossein Sahebkar
Nov 30, 2020·Seminars in Cancer Biology·Giovanna RevillaJoan Carles Escolà-Gil

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Methods Mentioned

BETA
biopsy
PCA

Software Mentioned

Fimlab
SPSS Statistics

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