Serum cholinesterase activity in burned patients. I: biochemical findings.

Acta Anaesthesiologica Scandinavica
J Viby-MogensenJ Graae

Abstract

The purpose of the study was to determine the magnitude and the aetiology of alterations in serum cholinesterase activity (pseudocholinesterase) in burned patients. Sixty burned patients with an estimated area of burn between 3 and 72% of body surface were investigated. Serum cholinesterase activity, serum albumin concentration and serum bilirubin were measured at various time intervals. The magnitude as well as the rate of fall of serum cholinesterase activity was found to be closely correlated with the severity of burn injury. Minimum levels were often reached 5 to 6 days after the burn injury, at which time the activity might have been depressed by more than 80 per cent. In the most severely burned patients, the activity sometimes remained low for months despite wound healing. Apart from the severity of the burn injury in the individual patient, several important factors determined the level of serum cholinesterase activity at a given time. These included the presence or absence of local or systemic infections, the event of recent surgery such as slough removal or skin grafting, and blood transfusions. The decrease in serum albumin concentration following the burn injury occurred earlier than the decrease in serum cholineste...Continue Reading

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Citations

Feb 1, 1996·Burns : Journal of the International Society for Burn Injuries·A E WerbaC Wolrab
Mar 20, 2002·Burns : Journal of the International Society for Burn Injuries·L-P KamolzM Frey
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Mar 1, 2011·British Journal of Anaesthesia·T-H Han, J A J Martyn
Jan 1, 1975·Acta Anaesthesiologica Scandinavica·J Viby-MogensenJ Graae
Jan 1, 1978·Acta Anaesthesiologica Scandinavica·H K HanelO B de Muckadell
Jul 24, 2004·Anesthesia and Analgesia·TaeHyung HanJ A Jeevendra Martyn
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Aug 1, 1987·Anaesthesia·Y Mehta, P Hole
Nov 1, 1986·Journal of Clinical Pharmacology·J MartynN G Goudsouzian
Jun 1, 1987·Burns, Including Thermal Injury·D T GaultF M Moody
Mar 6, 2018·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Ethan O BrysonMatthew Majeske
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Nov 30, 2020·Burns : Journal of the International Society for Burn Injuries·Karsten SchmidtStefan Hofer
Dec 12, 2021·Journal of Burn Care & Research : Official Publication of the American Burn Association·C TapkingC Hirche

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