PMID: 7528607Dec 1, 1994Paper

Serum chromogranin A in the differential diagnosis of Cushing's syndrome

European Journal of Endocrinology
F R NobelsS W Lamberts

Abstract

We evaluated whether measuring serum levels of chromogranin A, a marker of neuroendocrine tumours, could be useful in the differential diagnosis between pituitary, adrenal and ectopic causes of Cushing's syndrome. Thirty patients with Cushing's syndrome were studied. The localization of the tumours responsible was pituitary in 15, adrenal in 5 and ectopic in 10 patients. Serum concentrations of chromogranin A were measured in all patients. Petrosal sinus sampling for chromogranin A was performed in the cases with pituitary-dependent Cushing's syndrome. Immunohistochemical staining for chromogranin A was carried out on part of the tumour specimens. Slightly elevated serum levels of chromogranin A (range 223-262 micrograms/l) were detected in inferior petrosal sinus and peripheral venous samples from three patients with pituitary-dependent Cushing's syndrome. Serum chromogranin A showed no significant pituitary to peripheral gradient in these patients. Chromogranin A levels were not elevated in cases of adrenal Cushing's syndrome. Markedly elevated concentrations (range 270-13,900 micrograms/l) were shown in seven of 10 patients with neuroendocrine tumours with ectopic adrenocorticotrophin (ACTH) and/or corticotrophin-releasing h...Continue Reading

Citations

Aug 1, 1996·Hematology/oncology Clinics of North America·J H Keffer
May 28, 2009·The Journal of Clinical Endocrinology and Metabolism·Marina S ZemskovaLynnette K Nieman
Mar 11, 2010·Annals of Surgical Oncology·Irvin M ModlinMark Kidd
Dec 29, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·José Ángel Díaz Pérez, Maria Currás Freixes
Aug 7, 1998·European Journal of Clinical Investigation·F R NobelsS W Lamberts
Feb 1, 1997·The Journal of Urology·N KimuraH Nagura
Aug 14, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M C CerraG Alloatti
Oct 6, 2001·Frontiers in Neuroendocrinology·S W LambertsF R Nobels
Jun 12, 2010·Annales d'endocrinologie·M d'HerbomezUNKNOWN groupe des tumeurs endocrines (GTE France)

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