Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients.

Scientific Reports
Abhay P S RathoreAshley L St John

Abstract

Dengue induces a spectrum of severity in humans from the milder dengue fever to severe disease, or dengue hemorrhagic fever (DHF). Chymase is a candidate biomarker that may aid dengue prognosis. This prospective study aimed to identify whether warning signs of severe dengue, including hypovolemia and fluid accumulation, were associated with elevated chymase. Serum chymase levels were quantified prospectively and longitudinally in hospitalized pediatric dengue patients in Sri Lanka. Warning signs were determined based on daily clinical assessments, laboratory tests and ultrasound findings. Chymase was significantly elevated during the acute phase of disease in DHF or Severe dengue, defined by either the 1997 or 2009 WHO diagnosis guidelines, and persisted longer in the most severe patients. Chymase levels were higher in patients with narrow pulse pressure and clinical warning signs such as severe leakage, fluid accumulation, pleural effusion, gall-bladder wall thickening and rapid haematocrit rise concurrent with thrombocytopenia. No association between chymase and liver enlargement was observed. This study confirms that serum chymase levels are associated with DHF/Severe dengue disease in hospitalized pediatric patients. Chymas...Continue Reading

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Citations

Aug 29, 2020·Journal of Medical Virology·Ankit Kumar SahuKalpana Luthra
Feb 6, 2021·PloS One·Tehani SilvaGathsaurie Neelika Malavige
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Gathsaurie Neelika MalavigeGraham S Ogg
Jun 1, 2021·Journal of Leukocyte Biology·Rodolfo Soria-CastroRommel Chacón-Salinas

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Methods Mentioned

BETA
ELISA
blood collection
PCR

Software Mentioned

SPSS
Prism
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