PMID: 1201269Nov 1, 1975Paper

Serum colloidal osmotic pressure in the development of kwashiorkor and in recovery: its relationship to albumin and globulin concentrations and oedema

The British Journal of Nutrition
W A Coward

Abstract

1. Serum colloidal osmotic pressure was measured in children 'at risk' to kwashiorkor, in other with frank signs of the disease and during recovery. Simultaneous estimations of serum albumin and globulin concentrations and assessments of the extent of oedema were also made. 2. During the development of kwashiorkor, serum colloidal osmotic pressure did not decrease significantly until albumin concentration was 25-1--27-5 g/l. Above 30-0 g/1, colloidal osmotic pressure was maintained at normal levels during which time a significant reciprocal relationship existed between albumin and globulin concentrations. These findings provide support for suggestions that there may be on oncotic regulation of albumin synthesis. 3. Low albumin concentrations were mainly responsible for the low colloidal osmotic pressures found in children with kwashiorkor and in agreement and previous findings the threshold for the formation of oncotic oedema was found to be about 2-35--2-65 kN/m2. 4. Values for colloidal osmotic pressure calculated from serum albumin and gobulin concentrations using emprical formulas did not agree well with measured values and no constant correction factor suitable over the whole range of albumin concentrations found in rural ...Continue Reading

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Citations

May 1, 1979·The Proceedings of the Nutrition Society·W A Coward, M Fiorotto
Sep 1, 1983·Acta paediatrica Scandinavica·A M TripathiK N Agarwal
May 1, 1989·The British Journal of Nutrition·J A JolesH A Koomans
May 31, 2008·Annals of Tropical Paediatrics·Farook JahoorTerrence Forrester
Sep 29, 2011·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroshi YatsuhashiMichio Imawari
Jan 1, 1978·Transactions of the Royal Society of Tropical Medicine and Hygiene·D W CromptonP G Lunn
Jul 1, 1977·The British Journal of Nutrition·W A CowardP G Lunn
Mar 1, 1982·The British Journal of Surgery·P J Moore, R G Clark
Aug 1, 1980·Acta Anaesthesiologica Scandinavica·H Zetterström, G Arturson
Jan 1, 1977·The British Journal of Nutrition·W A Coward, M B Sawyer
Dec 1, 1988·Journal of the American College of Nutrition·S Mobarhan

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