Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population

Metabolism: Clinical and Experimental
Altan OnatHüsniye Yüksel

Abstract

We studied whether serum complement C3 (C3) is an independent determinant of incident cardiometabolic risk (coronary heart disease [CHD], metabolic syndrome [MetS], and type 2 diabetes mellitus). A cohort of 1220 adults of a general population (age, 53 +/- 10.5 years) was evaluated prospectively at 3.3 years follow-up using Cox proportional hazard regressions. Cardiometabolic risk factors were measured. Metabolic syndrome was identified by Adult Treatment Panel III criteria modified for male abdominal obesity. The C3 levels were associated significantly and linearly with serum triglycerides, waist circumference, and C-reactive protein (CRP), and inversely with current smoking but not with the marker of insulin resistance. In regression models for incident MetS, increasing C3 quartiles strongly predicted MetS in women and in both sexes combined after adjusting for all 5 MetS components and other confounders. Circulating C3 significantly predicted in each sex incident CHD independent of age, smoking status, and presence of MetS. Even after entering CRP, C3 predicted CHD with a relative risk of 1.35 (95% confidence interval, 1.09-1.67) for 1-SD increment of C3 in the total sample. Complement C3 tended to contribute, additively to ...Continue Reading

References

Apr 1, 1995·The American Journal of Medicine·A MuscariP Puddu
Sep 1, 1993·The Journal of Clinical Investigation·A BaldoK Cianflone
May 1, 1993·Metabolism: Clinical and Experimental·R GerminarioK Cianflone
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
May 23, 2001·Atherosclerosis·A Onat
Oct 17, 2001·Developmental and Comparative Immunology·I K ZarkadisJ D Lambris
Jan 25, 2003·Biochimica Et Biophysica Acta·Katherine CianfloneLan Ying Chen
Nov 23, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Y YangK Cianflone
Dec 21, 2005·Thrombosis and Haemostasis·Ramzi AjjanAngela M Carter
Apr 3, 2007·The American Journal of Cardiology·Anil PalikheMarja-Liisa Lokki
Dec 25, 2007·Nutrition & Metabolism·Aldi T KrajaIngrid B Borecki
Jan 15, 2008·Metabolism: Clinical and Experimental·Altan OnatGülay Hergenç
Sep 23, 2008·European Journal of Endocrinology·Ponce Cedric Fouejeu WambaKatherine Cianflone

❮ Previous
Next ❯

Citations

Mar 23, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Altan OnatKatherine Cianflone
Apr 24, 2014·European Journal of Clinical Investigation·Bo NilssonLars Lind
Apr 23, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·T TorresM Selores
Oct 12, 2010·International Journal of Cardiology·Marleen M J van GreevenbroekCoen D A Stehouwer
Feb 27, 2015·Diabetology & Metabolic Syndrome·Fernanda de Carvalho VidigalJosefina Bressan
Mar 10, 2015·Molecular Immunology·Andreea BarbuBo Nilsson
Nov 27, 2010·Journal of the American College of Cardiology·Altan Onat
Nov 20, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Altan OnatHüsniye Yüksel
Jul 16, 2014·Molecular Immunology·E HertleM M J van Greevenbroek
Jan 6, 2017·Clinical and Experimental Hypertension : CHE·Xue BaoKaijun Niu
Jan 20, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Helen Hermana M HermsdorffJ Alfredo Martínez
Jul 16, 2011·Expert Opinion on Pharmacotherapy·Altan Onat
Apr 18, 2018·Current Diabetes Reviews·Melanie CopenhaverRobert P Hoffman
Oct 14, 2017·The Journal of Clinical Endocrinology and Metabolism·Yan BornéGunnar Engström
Feb 2, 2021·Stroke; a Journal of Cerebral Circulation·Pinni YangJiang He

❮ Previous
Next ❯

Related Concepts

Related Feeds

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.