Serum complement factor I is associated with disease activity of systemic lupus erythematosus

Oncotarget
Min-Hua TsengJing-Long Huang

Abstract

Although aberrant complement activation is involved in the pathogenesis of systemic lupus erythematosus (SLE), the role of complement regulatory proteins in disease activity of SLE remains limited. We enrolled the pediatric-onset SLE patients from our cohort study over 10 years. The clinical and laboratory data including SLEDAI disease activity score, and serum complement factor H (CFH), CFI, CD46, C5a, and C5b-9 in the active and remission phases were determined. Glomerular C5b-9 deposition as a complement activity marker was also examined. Forty patients (35 female and 5 male, aged 13.9 ± 3.8 years) met the criteria of investigation were assessed. Fever and kidney were the most common symptom and organ involved, respectively. Mean SLEDAI in the active and remission phases were 12.6 vs 1.7, respectively. All patients exhibited lower serum C3, C4, CFH and CFI and higher serum anti-dsDNA and CD46 in the active pahse. There was a significant difference in serum CFH, CFI and CD46 between active and remissive phases. Serum CFI but not CFH and CD46 level was negatively correlated with SLEDAI score in active phase. Compared to classical activity markers, serum CFI was superior to C4 and anti-dsDNA in reflecting disease activity and a...Continue Reading

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Citations

Nov 14, 2019·Seminars in Immunology·Douwe J DijkstraLeendert A Trouw
Jan 17, 2021·Cells·María Galindo-Izquierdo, José Luis Pablos Alvarez
Mar 2, 2021·Frontiers in Immunology·Jacob J E KoopmanCees van Kooten
Aug 14, 2020·Journal of Proteome Research·Angelo D'AlessandroKirk C Hansen

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Methods Mentioned

BETA
ELISA

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SPSS

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