Serum concentration of endogenous G-CSF in women during the menstrual cycle and pregnancy

European Journal of Clinical Investigation
S MakinodaS Fujimoto

Abstract

Although granulocyte-colony stimulating factor (G-CSF) is commonly used in the field of supportive therapy for cancer treatment, the serum concentration of endogenous G-CSF in healthy women is still obscure due to the low sensitivity (30 pg mL-1) of the usual enzyme immunoassay. With the development of a highly sensitive (1.0 pg mL-1) chemiluminescent immunoassay by Kiriyama et al., we have clarified the changes of serum G-CSF levels in healthy women during the menstrual cycle and pregnancy. The G-CSF concentration showed a peak value of 27.3 +/- 2.5 pg mL-1 (mean +/- SEM) at the ovulatory phase during the menstrual cycle, which is significantly higher than in all other phases (P < 0.0001, unpaired t-test). A significantly higher value compared to the menstrual cycle, except during the ovulatory phase, was also revealed throughout pregnancy (P < 0.0001, unpaired t-test). These results suggest that G-CSF plays an important role in ovulation and the maintenance of pregnancy.

References

Dec 1, 1992·Asia-Oceania Journal of Obstetrics and Gynaecology·M SaitoK Motoyoshi
Mar 31, 1989·Journal of Immunological Methods·H MotojimaM Fukushima
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H UzumakiY Umezawa
Feb 1, 1980·Biology of Reproduction·L L Espey
Nov 15, 1993·Clinica Chimica Acta; International Journal of Clinical Chemistry·R KiriyamaN Ohsawa

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Citations

Dec 1, 1996·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S MakinodaS Fujimoto
Nov 26, 2003·Journal of Reproductive Immunology·Rie ShinodaYoshinori Iwatani
Mar 17, 2010·Annales de dermatologie et de vénéréologie·E Wierzbicka-HainautG Guillet
Feb 28, 2015·Journal of Reproductive Immunology·Mona RahmatiNathalie Ledee
Jun 24, 2016·The Journal of Dermatology·Shinsuke MatsuoTakahiro Satoh
May 16, 2000·Critical Reviews in Clinical Laboratory Sciences·R E Banks
Aug 28, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·K MatsubaraM Ito
Sep 10, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Hulusi Bulent ZeynelogluUtkun Moran
Nov 3, 2020·Frontiers in Immunology·Bahaa Abu-RayaPascal M Lavoie

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