Serum concentration of Reg IV in patients with colorectal cancer: overexpression and high serum levels of Reg IV are associated with liver metastasis

Oncology
Naohide OueWataru Yasui

Abstract

Regenerating islet-derived family, member 4 (regenerating gene type IV, Reg IV) is overexpressed in colorectal cancer (CRC). The aim of this study was to investigate the diagnostic utility of Reg IV determination in sera from patients with CRC. We examined the expression and distribution of Reg IV in CRC by immunohistochemistry and determined Reg IV levels in sera from patients with CRC by enzyme-linked immunosorbent assay. Immunostaining revealed that 23 of 80 (29%) CRC cases were positive for Reg IV. CRC cases with metastatic recurrence in the liver showed more frequently Reg IV staining than those without (p = 0.0102). Patients with CRC showing Reg IV staining had a significantly worse survival than those without Reg IV staining (p = 0.0117). Preoperatively, serum Reg IV concentrations were not elevated in CRC patients at stage 0-III, being in contrast to the significantly increased preoperative levels in stage IV CRC patients with liver metastasis. These results suggest that Reg IV is a prognosticator for poor survival. Serum Reg IV concentration may predict CRC recurrence in the liver.

References

Oct 20, 1995·Science·V E VelculescuK W Kinzler
Dec 1, 1996·Nature Biotechnology·D J LockhartE L Brown
Nov 14, 2000·The American Journal of Pathology·H KuniyasuI J Fidler
Apr 20, 2002·Clinical & Experimental Metastasis·L OliverF M Vallette
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Sabine VioletteThécla Lesuffleur
Jun 24, 2003·The American Journal of Pathology·Meerit KämäräinenLeif C Andersson
Jan 30, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Apichart NanakinTsutomu Chiba

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Citations

Jan 13, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kohei NakataMasazumi Tsuneyoshi
Mar 31, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hidetsugu YamagishiTakahiro Fujimori
Jun 21, 2012·Diagnostic Pathology·Qi WangYanyang Tu
Feb 23, 2011·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Hua-chuan ZhengYasuo Takano
Jul 25, 2012·World Journal of Gastroenterology : WJG·Masakatsu Numata, Takashi Oshima
Mar 23, 2013·Cell and Tissue Research·Atle van Beelen GranlundArne Kristian Sandvik
Feb 4, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Tetsuji SawadaYoshihiko Maehara
Mar 19, 2013·Regulatory Peptides·Kukka Heiskala, Leif C Andersson
Apr 27, 2010·Cancer Genetics and Cytogenetics·Ying GuoPeilin Huang
Sep 11, 2009·Human Pathology·Hua-Chuan ZhengYasuo Takano
Mar 8, 2011·Journal of Surgical Oncology·Masakatsu NumataToshio Imada
Mar 30, 2011·International Journal of Cancer. Journal International Du Cancer·Kathryn VanderlaagMary J Janatpour
May 8, 2013·International Journal of Cancer. Journal International Du Cancer·Shun LuAsta Försti
Aug 13, 2015·Pharmacogenomics·Maria Anna SmolleArmin Gerger
Dec 3, 2014·The Journal of Surgical Research·Kozo KataokaAkira Arimoto
Aug 31, 2016·Proceedings of the National Academy of Sciences of the United States of America·Nobuo SasakiHans Clevers
Sep 22, 2015·Scientific Reports·Yoshihiro KawasakiTetsu Akiyama
Jan 8, 2017·Molecular & Cellular Proteomics : MCP·Anuli Christiana UzozieGiancarlo Marra
Mar 16, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Kapo SaukkonenCaj Haglund
Jan 1, 2010·Experimental and Therapeutic Medicine·Naotsugu SekoWataru Yasui
Dec 20, 2018·BMC Cancer·Vincenza BarresiDaniele F Condorelli
Jan 26, 2021·Frontiers in Oncology·Junyan ZhangZhenning Wang

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