PMID: 3745883Jan 1, 1986Paper

Serum concentration of the aminoterminal procollagen type III peptide in the rat reflects early formation of connective tissue in experimental liver cirrhosis

Journal of Hepatology
D SchuppanE G Hahn

Abstract

A specific and sensitive radioimmunoassay for the rat aminoterminal procollagen type III peptide (PIIIP) was developed which allowed easy and sequential measurement of this peptide in the serum of individual animals. PIIIP in sera of 1-week-old rats was high (60 +/- 15.4 ng, 1 SD) falling to 15.7 +/- 4.3 ng/ml (1 SD) at 7 weeks and 6.7 +/- 2.6 ng/ml (1 SD) at 12 weeks of age. Adult animals (above 6 months of age) showed serum PIIIP levels in the narrow range of 2.5 +/- 2.33 ng/ml (2.5 SD). CCl4-induced liver damage in adult rats produced an elevated serum PIIIP (median 9.1; range 2.6-45.2 ng/ml) already after 2 weeks, rising to a mean of 33.8 ng/ml (range 22.0-47 ng/ml) after 6 weeks of continued CCl4-intoxication. In the same animals at 6 weeks, hepatic hydroxyproline was almost 5 times higher in the CCl4-group (mean 493.2; range 343.1-582.3 micrograms/100 mg dry weight) when compared with controls (109 +/- 14 micrograms/100 mg dry weight, 1 SD). These results are in complete analogy to those reported for PIIIP in sera of growing children, healthy human adults and patients with fibrogenic liver disease. Elevated serum PIIIP in rats with experimental liver fibrosis predicts the deposition of excess hepatic collagen. This novel ...Continue Reading

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Citations

May 31, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M GressnerJ Kropf
Aug 28, 2001·British Journal of Pharmacology·K RomboutsA Geerts
Sep 1, 1987·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·A M GressnerW Tittor
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·U Hahn
Oct 13, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Dj LeemingMa Karsdal
Aug 27, 2015·Journal of Hepatology·Morten A KarsdalDetlef Schuppan
Dec 16, 1998·The Journal of Veterinary Medical Science·J J Cho, Y S Lee
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T NikiA Geerts
Oct 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K L RudolphM P Manns
Aug 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A GeertsE Wisse
Apr 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ShahinS M Abdel Razek
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J RuwartE G Hahn
Jul 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S MilaniH Stein
Jan 1, 1990·Veterinary Clinical Pathology·Charles CorneliusBlaine Lee
Sep 1, 1989·Scandinavian Journal of Gastroenterology·M Salaspuro
Jun 5, 2017·Advanced Drug Delivery Reviews·Giuseppe MazzaKrista Rombouts

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