PMID: 3770065Jan 1, 1986Paper

Serum concentrations and safety of rimantadine in paediatric patients

European Journal of Clinical Pharmacology
M C Nahata, M T Brady

Abstract

Rimantadine has been shown to be more active in vitro and less toxic than amantadine in adults with influenza A disease. Because of a lack of studies in pediatric patients, we designed a study to evaluate serum concentrations and adverse effects of rimantadine in infants receiving repeated doses. Fourteen hospitalized infants (ages 1-10 months) were given rimantadine syrup at 3 mg/kg/dose in single daily doses during influenza season. Blood samples were obtained prior to dose and at various intervals up to 8 h after doses on the fifth to ninth days of therapy. Adverse effects were assessed based on clinical status, activity level, hematologic and biochemical parameters during 10-day therapy. Steady-state rimantadine peak serum concentration ranged from 100 to 574 ng/ml and time to achieve peak concentration ranged from 2.5 to 6.0 h after the doses. No adverse effects were seen except hematuria in one infant; this patient had the highest rimantadine concentration and longest treatment duration. Hematuria resolved during a follow-up evaluation on the ninth day after stopping therapy. Our data suggest that rimantadine can be given safely at repeated doses of 3 mg/kg/dose in a convenient once-daily regimen; the steady-state peak se...Continue Reading

References

Jun 1, 1976·The Journal of Infectious Diseases·J S WalkerR O Spertzel
Nov 1, 1976·The Journal of Infectious Diseases·R B Couch, G G Jackson
Mar 20, 1981·JAMA : the Journal of the American Medical Association·L P Van VorisR G Douglas
May 1, 1981·Reviews of Infectious Diseases·D M ZlydnikovL E Kamforin
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Sep 2, 1982·The New England Journal of Medicine·R G Douglas
May 1, 1980·Antimicrobial Agents and Chemotherapy·F G HaydenR G Douglas

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Citations

Dec 1, 1992·Journal of Clinical Pharmacy and Therapeutics·M C Nahata
Mar 20, 2009·American Journal of Physiology. Cell Physiology·Phillip C EckelsChristopher C Silliman
Mar 2, 2006·Pharmacotherapy·Kara A Townsend, Lea S Eiland
Jun 25, 2009·Seminars in Hematology·Timothy Jancel, Scott R Penzak
Mar 1, 1995·The Annals of Pharmacotherapy·S M Wintermeyer, M C Nahata

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